Preimplantation Genetic Screening to Improve in Vitro Fertilization Pregnancy Rates: a Prospective Randomized Controlled Trial

Overview

Journal Fertil Steril

Specialty Reproductive Medicine

Date 2007 Dec 7

PMID 18061593

Citations 9

Authors

Jennifer E Mersereau

Eugene Pergament

Xingqi Zhang

Magdy P Milad

Affiliations

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Abstract

This prospective randomized controlled pilot trial was designed to evaluate whether prescreening embryos for aneuploidy can improve clinical outcomes in infertile patients undergoing IVF, without limiting to poor prognosis patients. Although there was no statistically significant improvement in live birth rates or implantation rates in this pilot study, there was a trend toward improved clinical outcomes, indicating that future multicenter randomized trials are needed.

Citing Articles

Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis.

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PMID: 38803301 PMC: 11266849. DOI: 10.5468/ogs.24028.

Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation.

Cornelisse S, Zagers M, Kostova E, Fleischer K, van Wely M, Mastenbroek S Cochrane Database Syst Rev. 2020; 9:CD005291.

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Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer.

Boynukalin F, Gultomruk M, Cavkaytar S, Turgut E, Findikli N, Serdarogullari M PLoS One. 2020; 15(1):e0227619.

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The relationship between the percent of euploid embryo and the tolerance of embryo biopsy in preimplantation genetic screening: A systematic review and meta-analysis of randomized controlled trials.

Jiang X, Zhao C, Xu W, Zhang R Medicine (Baltimore). 2019; 98(25):e15968.

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Preimplantation genetic diagnosis: an update on current technologies and ethical considerations.

Sueoka K Reprod Med Biol. 2017; 15(2):69-75.

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