Preimplantation Genetic Screening: a Practical Guide

Overview

Journal Clin Med Insights Reprod Health

Publisher Sage Publications

Specialty Reproductive Medicine

Date 2014 Jan 24

PMID 24453517

Citations 6

Authors

Paul R Brezina

Raymond W Ke

William H Kutteh

Affiliations

Soon will be listed here.

Abstract

The past several decades have seen tremendous advances in the field of medical genetics. The application of genetic technologies to the field of reproductive medicine has ushered in a new era of medicine that is likely to greatly expand in the coming years. Concurrent with an in vitro fertilization (IVF) cycle, it is now possible to obtain a cellular biopsy from a developing embryo and genetically evaluate this sample with increasing sophistication and detail. Preimplantation genetic screening (PGS) is the practice of determining the presence of aneuploidy (either too many or too few chromosomes) in a developing embryo. However, how and in whom PGS should be offered is a topic of much debate.

Citing Articles

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Gao F, Chen L, Bo S, Yao Y, Xu Z, Ding Q PLoS One. 2021; 16(5):e0251971.

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Reproductive options for families at risk of Osteogenesis Imperfecta: a review.

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The outcome of human mosaic aneuploid blastocysts after intrauterine transfer: A retrospective study.

Hong B, Hao Y Medicine (Baltimore). 2020; 99(9):e18768.

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Pre-implantation genetic testing: decisional factors to accept or decline among in vitro fertilization patients.

Lamb B, Johnson E, Francis L, Fagan M, Riches N, Canada I J Assist Reprod Genet. 2018; 35(9):1605-1612.

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Molecular analysis of DNA in blastocoele fluid using next-generation sequencing.

Zhang Y, Li N, Wang L, Sun H, Ma M, Wang H J Assist Reprod Genet. 2016; 33(5):637-645.

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