Transcriptional Regulatory Circuits: Predicting Numbers from Alphabets

Overview

Journal Science

Specialty Science

Date 2009 Jul 25

PMID 19628860

Citations 96

Authors

Harold D Kim

Tal Shay

Erin K OShea

Aviv Regev

Affiliations

Soon will be listed here.

Abstract

Transcriptional regulatory circuits govern how cis and trans factors transform signals into messenger RNA (mRNA) expression levels. With advances in quantitative and high-throughput technologies that allow measurement of gene expression state in different conditions, data that can be used to build and test models of transcriptional regulation is being generated at a rapid pace. Here, we review experimental and computational methods used to derive detailed quantitative circuit models on a small scale and cruder, genome-wide models on a large scale. We discuss the potential of combining small- and large-scale approaches to understand the working and wiring of transcriptional regulatory circuits.

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