Transcriptional Plasticity Drives Leukemia Immune Escape

Overview

Journal Blood Cancer Discov

Specialties Hematology
Oncology

Date 2022 Jun 16

PMID 35709529

Authors

Kenneth Eagle

Taku Harada

Jeremie Kalfon

Monika W Perez

Yaser Heshmati

Jazmin Ewers

Jost Vrabic Koren

Joshua M Dempster

Guillaume Kugener

Vikram R Paralkar

Charles Y Lin

Neekesh V Dharia

Kimberly Stegmaier

Stuart H Orkin

Maxim Pimkin

Affiliations

Soon will be listed here.

Abstract

Significance: Our findings point to an adaptive transcriptional mechanism of AML evolution after allogeneic transplantation whereby combinatorial fluctuations of TF expression under immune pressure result in the selection of cells with a silenced T-cell stimulation program. This article is highlighted in the In This Issue feature, p. 369.

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