Efficacy of Emodepside Plus Praziquantel Tablets (Profender Tablets for Dogs) Against Mature and Immature Cestode Infections in Dogs

Overview

Journal Parasitol Res

Specialty Parasitology

Date 2009 Jul 4

PMID 19575223

Citations 8

Authors

Iris Schroeder

Gertraut Altreuther

Annette Schimmel

Peter Deplazes

Dawid J Kok

Manuela Schnyder

Klemens J Krieger

Affiliations

Soon will be listed here.

Abstract

The efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against intestinal cestodes was investigated in four randomised, blinded placebo-controlled dose confirmation studies in dogs experimentally infected with Echinococcus granulosus or E. multilocularis and in dogs naturally infected with Dipylidium caninum or Taenia spp. The tablets were used at the minimum recommended dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. The studies demonstrated 100% efficacy against mature and immature E. granulosus and E. multilocularis and mature Taenia spp. and D. caninum. Additionally, one of the studies demonstrated non-interference of emodepside with the efficacy of praziquantel against D. caninum. No side effects of the treatment were observed. It is concluded that emodepside plus praziquantel tablets are safe and effective against mature and immature stages of E. granulosus and E. multilocularis and mature stages of Taenia spp. and D. caninum.

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