High-speed Spectral-domain Optical Coherence Tomography at 1.3 Mum Wavelength

Overview

Journal Opt Express

Specialties Biophysics
Ophthalmology

Date 2009 May 28

PMID 19471496

Citations 96

Authors

S Yun

G Tearney

B Bouma

B Park

Johannes de Boer

Affiliations

Soon will be listed here.

Abstract

We demonstrate a high-speed spectral domain optical coherence tomography (SD-OCT) system capable of acquiring individual axial scans in 24.4 micros at a rate of 19,000 axial scans per second, using an InGaAs line scan camera and broadband light source centered at 1.31microm. Sensitivity of >105 dB over a 2-mm depth range was obtained with a free-space axial resolution of 12-14 microm, in agreement with our signal-to-noise ratio predictions. Images of human tissue obtained in vivo with SD-OCT show similar penetration depths to those obtained with state-of-the-art time domain OCT despite the ten-fold higher image acquisition speed. These results demonstrate the potential of 1.3 microm SD-OCT for high-speed and high-sensitivity imaging in patients.

Citing Articles

Basis function model to extract the combined confocal and fall-off function from multiple optical coherence tomography A-scans.

Phan D, Were M, Weitkamp J, Bowden A J Biomed Opt. 2025; 30(2):025003.

PMID: 40027922 PMC: 11868661. DOI: 10.1117/1.JBO.30.2.025003.

Fresnel biprism common-path low-coherence digital holography for dynamic light scattering spectroscopy of biological materials.

Goodwin G, Lim D, Mahajan S, Nolte D Biomed Opt Express. 2025; 16(2):806-820.

PMID: 39958857 PMC: 11828459. DOI: 10.1364/BOE.543308.

Method for Extracting Optical Element Information Using Optical Coherence Tomography.

Nie J, Wang Y, Wang D, Ding Y, Zhou C, Wang J Sensors (Basel). 2024; 24(21).

PMID: 39517852 PMC: 11548131. DOI: 10.3390/s24216953.

Microscopic Small Airway Abnormalities Identified in Early Idiopathic Pulmonary Fibrosis Using Endobronchial Optical Coherence Tomography.

Berigei S, Nandy S, Yamamoto S, Raphaely R, DeCoursey A, Lee J Am J Respir Crit Care Med. 2024; 210(4):473-483.

PMID: 38747674 PMC: 11351792. DOI: 10.1164/rccm.202401-0249OC.

Bichromatic tetraphasic full-field optical coherence microscopy.

Iyer R, Zurauskas M, Rao Y, Chaney E, Boppart S J Biomed Opt. 2024; 29(Suppl 2):S22704.

PMID: 38584966 PMC: 10996847. DOI: 10.1117/1.JBO.29.S2.S22704.

References

Leitgeb R, Hitzenberger C, Fercher A . Performance of fourier domain vs. time domain optical coherence tomography. Opt Express. 2009; 11(8):889-94. DOI: 10.1364/oe.11.000889. View

Nassif N, Cense B, Park B, Yun S, Chen T, Bouma B . In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography. Opt Lett. 2004; 29(5):480-2. DOI: 10.1364/ol.29.000480. View

Wojtkowski M, Bajraszewski T, Targowski P, Kowalczyk A . Real-time in vivo imaging by high-speed spectral optical coherence tomography. Opt Lett. 2003; 28(19):1745-7. DOI: 10.1364/ol.28.001745. View

Wojtkowski M, Leitgeb R, Kowalczyk A, Bajraszewski T, Fercher A . In vivo human retinal imaging by Fourier domain optical coherence tomography. J Biomed Opt. 2002; 7(3):457-63. DOI: 10.1117/1.1482379. View

Golubovic B, Bouma B, Tearney G, Fujimoto J . Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser. Opt Lett. 2008; 22(22):1704-6. DOI: 10.1364/ol.22.001704. View

Chinn S, Swanson E, Fujimoto J . Optical coherence tomography using a frequency-tunable optical source. Opt Lett. 1997; 22(5):340-2. DOI: 10.1364/ol.22.000340. View

Yun S, Tearney G, de Boer J, Iftimia N, Bouma B . High-speed optical frequency-domain imaging. Opt Express. 2009; 11(22):2953-63. PMC: 2758565. DOI: 10.1364/oe.11.002953. View

Ha Usler G, Lindner M . "Coherence radar" and "spectral radar"-new tools for dermatological diagnosis. J Biomed Opt. 2012; 3(1):21-31. DOI: 10.1117/1.429899. View

Swanson E, Huang D, Hee M, Fujimoto J, Lin C, Puliafito C . High-speed optical coherence domain reflectometry. Opt Lett. 2009; 17(2):151-3. DOI: 10.1364/ol.17.000151. View

10.

Bouma B, Tearney G . Clinical imaging with optical coherence tomography. Acad Radiol. 2002; 9(8):942-53. DOI: 10.1016/s1076-6332(03)80465-8. View

11.

Wojtkowski M, Kowalczyk A, Leitgeb R, Fercher A . Full range complex spectral optical coherence tomography technique in eye imaging. Opt Lett. 2007; 27(16):1415-7. DOI: 10.1364/ol.27.001415. View

12.

Tearney G, Yabushita H, Houser S, Aretz H, Jang I, Schlendorf K . Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography. Circulation. 2003; 107(1):113-9. DOI: 10.1161/01.cir.0000044384.41037.43. View

13.

de Boer J, Cense B, Park B, Pierce M, Tearney G, Bouma B . Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. Opt Lett. 2003; 28(21):2067-9. DOI: 10.1364/ol.28.002067. View

14.

Choma M, Sarunic M, Yang C, Izatt J . Sensitivity advantage of swept source and Fourier domain optical coherence tomography. Opt Express. 2009; 11(18):2183-9. DOI: 10.1364/oe.11.002183. View