Attenuation Coefficient Estimation in Fourier-domain OCT of Multi-layered Phantoms

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2021 Jun 14

PMID 34123501

Citations 3

Authors

Babak Ghafaryasl

Koenraad A Vermeer

Jeroen Kalkman

Tom Callewaert

Johannes F de Boer

Lucas J van Vliet

Affiliations

Soon will be listed here.

Abstract

Optical properties, such as the attenuation coefficients of multi-layer tissue samples, could be used as a biomarker for diagnosis and disease progression in clinical practice. In this paper, we present a method to estimate the attenuation coefficients in a multi-layer sample by fitting a single scattering model for the OCT signal to the recorded OCT signal. In addition, we employ numerical simulations to obtain the theoretically achievable precision and accuracy of the estimated parameters under various experimental conditions. Finally, the method is applied to two sets of measurements obtained from a multi-layer phantom by two experimental OCT systems: one with a large and one with a small Rayleigh length. Numerical and experimental results show an accurate estimation of the attenuation coefficients when using multiple B-scans.

Citing Articles

Automated segmentation and quantification of calcified drusen in 3D swept source OCT imaging.

Lu J, Cheng Y, Li J, Liu Z, Shen M, Zhang Q Biomed Opt Express. 2023; 14(3):1292-1306.

PMID: 36950236 PMC: 10026581. DOI: 10.1364/BOE.485999.

Integrating a pressure sensor with an OCT handheld probe to facilitate imaging of microvascular information in skin tissue beds.

Shi Y, Lu J, Le N, Wang R Biomed Opt Express. 2023; 13(11):6153-6166.

PMID: 36733756 PMC: 9872897. DOI: 10.1364/BOE.473013.

Depth-resolved visualization and automated quantification of hyperreflective foci on OCT scans using optical attenuation coefficients.

Zhou H, Liu J, Laiginhas R, Zhang Q, Cheng Y, Zhang Y Biomed Opt Express. 2022; 13(8):4175-4189.

PMID: 36032584 PMC: 9408241. DOI: 10.1364/BOE.467623.

References

Schmitt J, Knuttel A, Yadlowsky M, Eckhaus M . Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering. Phys Med Biol. 1994; 39(10):1705-20. DOI: 10.1088/0031-9155/39/10/013. View

Faber D, van der Meer F, Aalders M, van Leeuwen T . Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography. Opt Express. 2009; 12(19):4353-65. DOI: 10.1364/opex.12.004353. View

Tomlins P, Adegun O, Hagi-Pavli E, Piper K, Bader D, Fortune F . Scattering attenuation microscopy of oral epithelial dysplasia. J Biomed Opt. 2011; 15(6):066003. DOI: 10.1117/1.3505019. View

Stefan S, Jeong K, Polucha C, Tapinos N, Toms S, Lee J . Determination of confocal profile and curved focal plane for OCT mapping of the attenuation coefficient. Biomed Opt Express. 2018; 9(10):5084-5099. PMC: 6179411. DOI: 10.1364/BOE.9.005084. View

Alamouti B, Funk J . Retinal thickness decreases with age: an OCT study. Br J Ophthalmol. 2003; 87(7):899-901. PMC: 1771773. DOI: 10.1136/bjo.87.7.899. View

Braaf B, Vermeer K, Vienola K, de Boer J . Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans. Opt Express. 2012; 20(18):20516-34. DOI: 10.1364/OE.20.020516. View

McLaughlin R, Scolaro L, Robbins P, Saunders C, Jacques S, Sampson D . Parametric imaging of cancer with optical coherence tomography. J Biomed Opt. 2010; 15(4):046029. DOI: 10.1117/1.3479931. View

Barwari K, de Bruin D, Cauberg E, Faber D, van Leeuwen T, Wijkstra H . Advanced diagnostics in renal mass using optical coherence tomography: a preliminary report. J Endourol. 2011; 25(2):311-5. DOI: 10.1089/end.2010.0408. View

Manjunath V, Taha M, Fujimoto J, Duker J . Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography. Am J Ophthalmol. 2010; 150(3):325-329.e1. PMC: 2926223. DOI: 10.1016/j.ajo.2010.04.018. View

10.

Kodach V, Faber D, van Marle J, van Leeuwen T, Kalkman J . Determination of the scattering anisotropy with optical coherence tomography. Opt Express. 2011; 19(7):6131-40. DOI: 10.1364/OE.19.006131. View

11.

Zhang Q, Wu X, Tang T, Zhu S, Yao Q, Gao B . Quantitative analysis of rectal cancer by spectral domain optical coherence tomography. Phys Med Biol. 2012; 57(16):5235-44. PMC: 3691818. DOI: 10.1088/0031-9155/57/16/5235. View

12.

Yun S, Tearney G, Bouma B, Park B, de Boer J . High-speed spectral-domain optical coherence tomography at 1.3 mum wavelength. Opt Express. 2009; 11(26):3598-604. PMC: 2713046. DOI: 10.1364/oe.11.003598. View

13.

Ghafaryasl B, Vermeer K, Kalkman J, Callewaert T, de Boer J, van Vliet L . Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media. Biomed Opt Express. 2020; 11(11):6093-6107. PMC: 7687928. DOI: 10.1364/BOE.403283. View

14.

Vermeer K, Mo J, Weda J, Lemij H, de Boer J . Depth-resolved model-based reconstruction of attenuation coefficients in optical coherence tomography. Biomed Opt Express. 2014; 5(1):322-37. PMC: 3891343. DOI: 10.1364/BOE.5.000322. View

15.

Novosel J, Vermeer K, de Jong J, Wang Z, van Vliet L . Joint Segmentation of Retinal Layers and Focal Lesions in 3-D OCT Data of Topologically Disrupted Retinas. IEEE Trans Med Imaging. 2017; 36(6):1276-1286. DOI: 10.1109/TMI.2017.2666045. View

16.

Thrane L, Yura H, Andersen P . Analysis of optical coherence tomography systems based on the extended Huygens-Fresnel principle. J Opt Soc Am A Opt Image Sci Vis. 2000; 17(3):484-90. DOI: 10.1364/josaa.17.000484. View

17.

Barwari K, de Bruin D, Faber D, van Leeuwen T, de la Rosette J, Laguna M . Differentiation between normal renal tissue and renal tumours using functional optical coherence tomography: a phase I in vivo human study. BJU Int. 2012; 110(8 Pt B):E415-20. DOI: 10.1111/j.1464-410X.2012.11197.x. View

18.

van Soest G, Goderie T, Regar E, Koljenovic S, van Leenders G, Gonzalo N . Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging. J Biomed Opt. 2010; 15(1):011105. DOI: 10.1117/1.3280271. View

19.

Vermeer K, van der Schoot J, Lemij H, de Boer J . RPE-normalized RNFL attenuation coefficient maps derived from volumetric OCT imaging for glaucoma assessment. Invest Ophthalmol Vis Sci. 2012; 53(10):6102-8. DOI: 10.1167/iovs.12-9933. View

20.

Smith G, Dwork N, OConnor D, Sikora U, Lurie K, Pauly J . Automated, Depth-Resolved Estimation of the Attenuation Coefficient From Optical Coherence Tomography Data. IEEE Trans Med Imaging. 2015; 34(12):2592-602. PMC: 4714956. DOI: 10.1109/TMI.2015.2450197. View