Beyond NMR Spectra of Antimicrobial Peptides: Dynamical Images at Atomic Resolution and Functional Insights

Overview

Journal Solid State Nucl Magn Reson

Publisher Elsevier

Specialty Nuclear Medicine

Date 2009 Apr 24

PMID 19386477

Citations 56

Authors

Ayyalusamy Ramamoorthy

Affiliations

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Abstract

There is a considerable current interest in understanding the function of antimicrobial peptides for the development of potent novel antibiotic compounds with a very high selectivity. Since their interaction with the cell membrane is the major driving force for their function, solid-state NMR spectroscopy is the unique method of choice to study these insoluble, non-crystalline, membrane-peptide complexes. Here I discuss solid-state NMR studies of antimicrobial peptides that have reported high-resolution structure, dynamics, orientation, and oligomeric states of antimicrobial peptides in a membrane environment, and also address important questions about the mechanism of action at atomic-level resolution. Increasing number of solid-state NMR applications to antimicrobial peptides are expected in the near future, as these compounds are promising candidates to overcome ever-increasing antibiotic resistance problem and are well suited for the development and applications of solid-state NMR techniques.

Citing Articles

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Structure-activity relationships of antibacterial peptides.

Ciulla M, Gelain F Microb Biotechnol. 2023; 16(4):757-777.

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Biophysical approaches for exploring lipopeptide-lipid interactions.

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Magnetic Alignment of Polymer Nanodiscs Probed by Solid-State NMR Spectroscopy.

Ravula T, Kim J, Lee D, Ramamoorthy A Langmuir. 2020; 36(5):1258-1265.

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