Ayyalusamy Ramamoorthy
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Explore the profile of Ayyalusamy Ramamoorthy including associated specialties, affiliations and a list of published articles.
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315
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8816
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Recent Articles
1.
Saha J, Wolszczak A, Kaur N, Widanage M, McCalpin S, Fu R, et al.
bioRxiv
. 2025 Jan;
PMID: 39868250
Misfolding and aggregation of proteins into amyloidogenic assemblies are key features of several metabolic and neurodegenerative diseases. Human insulin has long been known to form amyloid fibrils under various conditions,...
2.
Interplay between Antimicrobial Peptides and Amyloid Proteins in Host Defense and Disease Modulation
Wani N, Gazit E, Ramamoorthy A
Langmuir
. 2024 Nov;
40(48):25355-25366.
PMID: 39564995
The biological properties of antimicrobial peptides (AMPs) and amyloid proteins and their cross-talks have gained increasing attention due to their potential implications in both host defense mechanisms and amyloid-related diseases....
3.
Liu S, Kumar K, Bell T, Ramamoorthy A, Van Winkle D, Lenhert S
Membranes (Basel)
. 2024 Aug;
14(8).
PMID: 39195420
Lipids have not traditionally been considered likely candidates for catalyzing reactions in biological systems. However, there is significant evidence that aggregates of amphiphilic compounds are capable of catalyzing reactions in...
4.
McCalpin S, Mechakra L, Ivanova M, Ramamoorthy A
Protein Sci
. 2024 Jul;
33(8):e5119.
PMID: 39012029
Despite causing over 1 million deaths annually, Type 2 Diabetes (T2D) currently has no curative treatments. Aggregation of the islet amyloid polypeptide (hIAPP) into amyloid plaques plays an important role...
5.
McCalpin S, Khemtemourian L, Suladze S, Ivanova M, Reif B, Ramamoorthy A
Commun Biol
. 2024 Jun;
7(1):776.
PMID: 38937578
Aggregation of the human islet amyloid polypeptide (hIAPP) contributes to the development and progression of Type 2 Diabetes (T2D). hIAPP aggregates within a few hours at few micromolar concentration in...
6.
Lim J, Zhang S, Heo J, Widanage M, Ramamoorthy A, Kim J
ACS Appl Mater Interfaces
. 2024 Jun;
16(24):31864-31872.
PMID: 38836337
While polydopamine (PDA) possesses the surface-independent adhesion property of mussel-binding proteins, significant differences exist between them. Particularly, PDA's short and rigid backbone differs from the long and flexible protein sequence...
7.
Krishnarjuna B, Sharma G, Hiiuk V, Struppe J, Nagorny P, Ivanova M, et al.
Anal Chem
. 2024 Jun;
96(23):9362-9369.
PMID: 38826107
Amyloid precursor protein (APP) plays a pivotal role in the pathology of Alzheimer's disease (AD). Since the fragmentation of the membrane-bound APP that results in the production of amyloid-β peptides...
8.
Krishnarjuna B, Sharma G, Hiiuk V, Struppe J, Nagorny P, Ivanova M, et al.
bioRxiv
. 2024 Apr;
PMID: 38659865
Amyloid precursor protein (APP) plays a pivotal role in the pathology of Alzheimer's disease. Since the fragmentation of the membrane-bound APP that results in the production of amyloid-beta peptides is...
9.
Fu R, Ramamoorthy A
J Phys Chem B
. 2024 Apr;
128(15):3527-3537.
PMID: 38568422
Despite the limitations posed by poor sensitivity, studies have reported the unique advantages of O based NMR spectroscopy to study systems existing in liquid, solid, or semisolid states. O NMR...
10.
Bhattacharjya S, Zhang Z, Ramamoorthy A
Biomolecules
. 2024 Mar;
14(3).
PMID: 38540740
Antimicrobial peptides (AMPs), as well as host defense peptides (HDPs), constitute the first line of defense as part of the innate immune system. Humans are known to express antimicrobial precursor...