In Vivo Analysis of Dendritic Cell Development and Homeostasis

Overview

Journal Science

Specialty Science

Date 2009 Mar 17

PMID 19286519

Citations 483

Authors

Kang Liu

Gabriel D Victora

Tanja A Schwickert

Pierre Guermonprez

Matthew M Meredith

Kaihui Yao

Fei-Fan Chu

Gwendalyn J Randolph

Alexander Y Rudensky

Michel Nussenzweig

Affiliations

Soon will be listed here.

Abstract

Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3.

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