Unravelling Monocyte Functions: from the Guardians of Health to the Regulators of Disease

Overview

Journal Discov Immunol

Specialty Allergy & Immunology

Date 2024 Oct 21

PMID 39430099

Authors

Alexander Mildner

Ki-Wook Kim

Simon Yona

Affiliations

Soon will be listed here.

Abstract

Monocytes are a key component of the innate immune system. They undergo intricate developmental processes within the bone marrow, leading to diverse monocyte subsets in the circulation. In a state of healthy homeostasis, monocytes are continuously released into the bloodstream, destined to repopulate specific tissue-resident macrophage pools where they fulfil tissue-specific functions. However, under pathological conditions monocytes adopt various phenotypes to resolve inflammation and return to a healthy physiological state. This review explores the nuanced developmental pathways and functional roles that monocytes perform, shedding light on their significance in both physiological and pathological contexts.

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