Oxidative Stress in Prostate Cancer

Overview

Journal Cancer Lett

Specialty Oncology

Date 2009 Feb 3

PMID 19185987

Citations 211

Authors

Lakshmipathi Khandrika

Binod Kumar

Sweaty Koul

Paul Maroni

Hari K Koul

Affiliations

Soon will be listed here.

Abstract

As prostate cancer and aberrant changes in reactive oxygen species (ROS) become more common with aging, ROS signaling may play an important role in the development and progression of this malignancy. Increased ROS, otherwise known as oxidative stress, is a result of either increased ROS generation or a loss of antioxidant defense mechanisms. Oxidative stress is associated with several pathological conditions including inflammation and infection. ROS are products of normal cellular metabolism and play vital roles in stimulation of signaling pathways in response to changing intra- and extracellular environmental conditions. Chronic increases in ROS over time are known to induce somatic mutations and neoplastic transformation. In this review we summarize the causes for increased ROS generation and its potential role in etiology and progression of prostate cancer.

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References

Harris M, Feldberg R, Lau K, Lazarus N, Cochrane D . Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate. Prostate. 2000; 44(1):19-25. DOI: 10.1002/1097-0045(20000615)44:1<19::aid-pros3>3.0.co;2-s. View

Stancik I, Luftenegger W, Klimpfinger M, Muller M, Hoeltl W . Effect of NIH-IV prostatitis on free and free-to-total PSA. Eur Urol. 2004; 46(6):760-4. DOI: 10.1016/j.eururo.2004.08.003. View

Isaacs J . The biology of hormone refractory prostate cancer. Why does it develop?. Urol Clin North Am. 1999; 26(2):263-73. DOI: 10.1016/s0094-0143(05)70066-5. View

Lee I, Cook N, Gaziano J, Gordon D, Ridker P, Manson J . Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA. 2005; 294(1):56-65. DOI: 10.1001/jama.294.1.56. View

Lim S, Sun C, Lambeth J, Marshall F, Amin M, Chung L . Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate. 2004; 62(2):200-7. DOI: 10.1002/pros.20137. View

Tsurusaki T, Aoki D, Kanetake H, Inoue S, Muramatsu M, Hishikawa Y . Zone-dependent expression of estrogen receptors alpha and beta in human benign prostatic hyperplasia. J Clin Endocrinol Metab. 2003; 88(3):1333-40. DOI: 10.1210/jc.2002-021015. View

Mansfield K, Guzy R, Pan Y, Young R, Cash T, Schumacker P . Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab. 2005; 1(6):393-9. PMC: 3141219. DOI: 10.1016/j.cmet.2005.05.003. View

Wartenberg M, Hoffmann E, Schwindt H, Grunheck F, Petros J, Arnold J . Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids. FEBS Lett. 2005; 579(20):4541-4549. DOI: 10.1016/j.febslet.2005.06.078. View

McCord J, Fridovich I . Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem. 1969; 244(22):6049-55. View

10.

Wei Y, Lu C, Lee H, Pang C, Ma Y . Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function. Ann N Y Acad Sci. 1999; 854:155-70. DOI: 10.1111/j.1749-6632.1998.tb09899.x. View

11.

Harman D . Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3):298-300. DOI: 10.1093/geronj/11.3.298. View

12.

Clark R . Activation of the neutrophil respiratory burst oxidase. J Infect Dis. 1999; 179 Suppl 2:S309-17. DOI: 10.1086/513849. View

13.

De Marzo A, Platz E, Sutcliffe S, Xu J, Gronberg H, Drake C . Inflammation in prostate carcinogenesis. Nat Rev Cancer. 2007; 7(4):256-69. PMC: 3552388. DOI: 10.1038/nrc2090. View

14.

Galanis A, Pappa A, Giannakakis A, Lanitis E, Dangaj D, Sandaltzopoulos R . Reactive oxygen species and HIF-1 signalling in cancer. Cancer Lett. 2008; 266(1):12-20. DOI: 10.1016/j.canlet.2008.02.028. View

15.

Bourdeau-Heller J, Oberley T . Prostate carcinoma cells selected by long-term exposure to reduced oxygen tension show remarkable biochemical plasticity via modulation of superoxide, HIF-1alpha levels, and energy metabolism. J Cell Physiol. 2007; 212(3):744-52. DOI: 10.1002/jcp.21069. View

16.

Fernandez-Checa J, Kaplowitz N, Garcia-Ruiz C, Colell A, Miranda M, Mari M . GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol. 1997; 273(1 Pt 1):G7-17. DOI: 10.1152/ajpgi.1997.273.1.G7. View

17.

Sadeghi-Nejad H, Seftel A . Sexual dysfunction and prostatitis. Curr Urol Rep. 2006; 7(6):479-84. DOI: 10.1007/s11934-006-0058-1. View

18.

Pilat M, Kamradt J, Pienta K . Hormone resistance in prostate cancer. Cancer Metastasis Rev. 1999; 17(4):373-81. DOI: 10.1023/a:1006166511344. View

19.

Lambeth J . Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med. 2007; 43(3):332-47. PMC: 2013737. DOI: 10.1016/j.freeradbiomed.2007.03.027. View

20.

Linja M, Savinainen K, Tammela T, Isola J, Visakorpi T . Expression of ERalpha and ERbeta in prostate cancer. Prostate. 2003; 55(3):180-6. DOI: 10.1002/pros.10242. View