Inflammation in Prostate Carcinogenesis

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2007 Mar 27

PMID 17384581

Citations 721

Authors

Angelo M De Marzo

Elizabeth A Platz

Siobhan Sutcliffe

Jianfeng Xu

Henrik Gronberg

Charles G Drake

Yasutomo Nakai

William B Isaacs

William G Nelson

Affiliations

Soon will be listed here.

Abstract

About 20% of all human cancers are caused by chronic infection or chronic inflammatory states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes that exposure to environmental factors such as infectious agents and dietary carcinogens, and hormonal imbalances lead to injury of the prostate and to the development of chronic inflammation and regenerative 'risk factor' lesions, referred to as proliferative inflammatory atrophy (PIA). By developing new experimental animal models coupled with classical epidemiological studies, genetic epidemiological studies and molecular pathological approaches, we should be able to determine whether prostate cancer is driven by inflammation, and if so, to develop new strategies to prevent the disease.

Citing Articles

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