Voltage-sensing Phosphatase: Actions and Potentials

Overview

Journal J Physiol

Specialty Physiology

Date 2008 Dec 17

PMID 19074969

Citations 61

Authors

Yasushi Okamura

Yoshimichi Murata

Hirohide Iwasaki

Affiliations

Soon will be listed here.

Abstract

Voltage sensors have been well studied in voltage-gated ion channels for neuronal excitation and muscle contraction. The recent discovery of a voltage-sensing phosphatase, VSP, has changed the idea that voltage sensors are unique to ion flux through membranes. Recent findings on mechanisms and potential applications of VSP are reviewed.

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References

Lundby A, Mutoh H, Dimitrov D, Akemann W, Knopfel T . Engineering of a genetically encodable fluorescent voltage sensor exploiting fast Ci-VSP voltage-sensing movements. PLoS One. 2008; 3(6):e2514. PMC: 2429971. DOI: 10.1371/journal.pone.0002514. View

Suh B, Hille B . Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol. 2005; 15(3):370-8. DOI: 10.1016/j.conb.2005.05.005. View

Huang C, Feng S, Hilgemann D . Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature. 1998; 391(6669):803-6. DOI: 10.1038/35882. View

Hossain M, Iwasaki H, Okochi Y, Chahine M, Higashijima S, Nagayama K . Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases. J Biol Chem. 2008; 283(26):18248-59. DOI: 10.1074/jbc.M706184200. View

Okamura Y . Biodiversity of voltage sensor domain proteins. Pflugers Arch. 2007; 454(3):361-71. DOI: 10.1007/s00424-007-0222-6. View

Suh B, Hille B . PIP2 is a necessary cofactor for ion channel function: how and why?. Annu Rev Biophys. 2008; 37:175-95. PMC: 2692585. DOI: 10.1146/annurev.biophys.37.032807.125859. View

Villalba-Galea C, Sandtner W, Starace D, Bezanilla F . S4-based voltage sensors have three major conformations. Proc Natl Acad Sci U S A. 2008; 105(46):17600-7. PMC: 2584729. DOI: 10.1073/pnas.0807387105. View

Miyawaki A . Fluorescence imaging of physiological activity in complex systems using GFP-based probes. Curr Opin Neurobiol. 2003; 13(5):591-6. DOI: 10.1016/j.conb.2003.09.005. View

Murata Y, Iwasaki H, Sasaki M, Inaba K, Okamura Y . Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature. 2005; 435(7046):1239-43. DOI: 10.1038/nature03650. View

10.

Alabi A, Bahamonde M, Jung H, Kim J, Swartz K . Portability of paddle motif function and pharmacology in voltage sensors. Nature. 2007; 450(7168):370-5. PMC: 2709416. DOI: 10.1038/nature06266. View

11.

Ramsey I, Moran M, Chong J, Clapham D . A voltage-gated proton-selective channel lacking the pore domain. Nature. 2006; 440(7088):1213-6. PMC: 4084761. DOI: 10.1038/nature04700. View

12.

Murata Y, Okamura Y . Depolarization activates the phosphoinositide phosphatase Ci-VSP, as detected in Xenopus oocytes coexpressing sensors of PIP2. J Physiol. 2007; 583(Pt 3):875-89. PMC: 2277204. DOI: 10.1113/jphysiol.2007.134775. View

13.

Iwasaki H, Murata Y, Kim Y, Hossain M, Worby C, Dixon J . A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2008; 105(23):7970-5. PMC: 2430346. DOI: 10.1073/pnas.0803936105. View

14.

Walker S, Leslie N, Perera N, Batty I, Downes C . The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J. 2004; 379(Pt 2):301-7. PMC: 1224073. DOI: 10.1042/BJ20031839. View

15.

Bruening-Wright A, Larsson H . Slow conformational changes of the voltage sensor during the mode shift in hyperpolarization-activated cyclic-nucleotide-gated channels. J Neurosci. 2007; 27(2):270-8. PMC: 6672073. DOI: 10.1523/JNEUROSCI.3801-06.2007. View

16.

Berger P, Schaffitzel C, Berger I, Ban N, Suter U . Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module. Proc Natl Acad Sci U S A. 2003; 100(21):12177-82. PMC: 218732. DOI: 10.1073/pnas.2132732100. View

17.

Odriozola L, Singh G, Hoang T, Chan A . Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. J Biol Chem. 2007; 282(32):23306-15. DOI: 10.1074/jbc.M611240200. View

18.

Long S, Campbell E, MacKinnon R . Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science. 2005; 309(5736):897-903. DOI: 10.1126/science.1116269. View

19.

Iijima M, Huang Y, Luo H, Vazquez F, Devreotes P . Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem. 2004; 279(16):16606-13. DOI: 10.1074/jbc.M312098200. View

20.

Baker B, Mutoh H, Dimitrov D, Akemann W, Perron A, Iwamoto Y . Genetically encoded fluorescent sensors of membrane potential. Brain Cell Biol. 2008; 36(1-4):53-67. PMC: 2775812. DOI: 10.1007/s11068-008-9026-7. View