Biodiversity of Voltage Sensor Domain Proteins

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2007 Mar 10

PMID 17347852

Citations 27

Authors

Yasushi Okamura

Affiliations

Soon will be listed here.

Abstract

The six-transmembrane type voltage-gated ion channels play an essential role in neuronal excitability, muscle contraction, and secretion. The voltage sensor domain (VSD) is the key element of voltage-gated ion channels for sensing transmembrane potential, and has been studied at the levels of both biophysics and protein structure. Two recently identified proteins containing VSD without a pore domain showed unexpected biological roles: regulation of phosphatase activity and proton permeation. These proteins not only provide novel platforms to understand mechanisms of voltage sensing and ion permeation but also highlight previously unappreciated roles of membrane potential in non-neuronal cells.

Citing Articles

The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase.

Kawai T, Morioka S, Miyata H, Andriani R, Akter S, Toma G Nat Commun. 2024; 15(1):7289.

PMID: 39181879 PMC: 11344830. DOI: 10.1038/s41467-024-51755-2.

Protons in Gating the Kv1.2 Channel: A Calculated Set of Protonation States in Response to Polarization/Depolarization of the Channel, with the Complete Proposed Proton Path from Voltage Sensing Domain to Gate.

Kariev A, Green M Membranes (Basel). 2022; 12(7).

PMID: 35877921 PMC: 9318985. DOI: 10.3390/membranes12070718.

Towards the Idea of Molecular Brains.

Timsit Y, Gregoire S Int J Mol Sci. 2021; 22(21).

PMID: 34769300 PMC: 8584932. DOI: 10.3390/ijms222111868.

Heterologous functional expression of ascidian Nav1 channels and close relationship with the evolutionary ancestor of vertebrate Nav channels.

Kawai T, Hashimoto M, Eguchi N, Nishino J, Jinno Y, Mori-Kreiner R J Biol Chem. 2021; 296:100783.

PMID: 34000300 PMC: 8192821. DOI: 10.1016/j.jbc.2021.100783.

The Role of Proton Transport in Gating Current in a Voltage Gated Ion Channel, as Shown by Quantum Calculations.

Kariev A, Green M Sensors (Basel). 2018; 18(9).

PMID: 30231473 PMC: 6163810. DOI: 10.3390/s18093143.

References

Maehama T, Taylor G, Dixon J . PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem. 2001; 70:247-79. DOI: 10.1146/annurev.biochem.70.1.247. View

Wang D, King S, Quill T, Doolittle L, Garbers D . A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. Nat Cell Biol. 2003; 5(12):1117-22. DOI: 10.1038/ncb1072. View

Lu Z, Klem A, Ramu Y . Coupling between voltage sensors and activation gate in voltage-gated K+ channels. J Gen Physiol. 2002; 120(5):663-76. PMC: 2229552. DOI: 10.1085/jgp.20028696. View

Reymond A, Marigo V, Yaylaoglu M, Leoni A, Ucla C, Scamuffa N . Human chromosome 21 gene expression atlas in the mouse. Nature. 2002; 420(6915):582-6. DOI: 10.1038/nature01178. View

Jaffe L, Cross N, Picheral B . Studies of the voltage-dependent polyspermy block using cross-species fertilization of amphibians. Dev Biol. 1983; 98(2):319-26. DOI: 10.1016/0012-1606(83)90362-7. View

Jaffe L, Sharp A, Wolf D . Absence of an electrical polyspermy block in the mouse. Dev Biol. 1983; 96(2):317-23. DOI: 10.1016/0012-1606(83)90168-9. View

Henderson L, Chappell J, Jones O . The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem J. 1987; 246(2):325-9. PMC: 1148280. DOI: 10.1042/bj2460325. View

Walker S, Downes C, Leslie N . TPIP: a novel phosphoinositide 3-phosphatase. Biochem J. 2001; 360(Pt 2):277-83. PMC: 1222227. DOI: 10.1042/0264-6021:3600277. View

Long S, Campbell E, MacKinnon R . Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science. 2005; 309(5736):903-8. DOI: 10.1126/science.1116270. View

10.

Tombola F, Pathak M, Isacoff E . How does voltage open an ion channel?. Annu Rev Cell Dev Biol. 2006; 22:23-52. DOI: 10.1146/annurev.cellbio.21.020404.145837. View

11.

Morgan D, Cherny V, Murphy R, Katz B, DeCoursey T . The pH dependence of NADPH oxidase in human eosinophils. J Physiol. 2005; 569(Pt 2):419-31. PMC: 1464255. DOI: 10.1113/jphysiol.2005.094748. View

12.

Ramsey I, Moran M, Chong J, Clapham D . A voltage-gated proton-selective channel lacking the pore domain. Nature. 2006; 440(7088):1213-6. PMC: 4084761. DOI: 10.1038/nature04700. View

13.

Fabiato A, Fabiato F . Calcium release from the sarcoplasmic reticulum. Circ Res. 1977; 40(2):119-29. DOI: 10.1161/01.res.40.2.119. View

14.

Hegle A, Marble D, Wilson G . A voltage-driven switch for ion-independent signaling by ether-à-go-go K+ channels. Proc Natl Acad Sci U S A. 2006; 103(8):2886-91. PMC: 1413768. DOI: 10.1073/pnas.0505909103. View

15.

Barish M, Baud C . A voltage-gated hydrogen ion current in the oocyte membrane of the axolotl, Ambystoma. J Physiol. 1984; 352:243-63. PMC: 1193209. DOI: 10.1113/jphysiol.1984.sp015289. View

16.

Suh B, Hille B . Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol. 2005; 15(3):370-8. DOI: 10.1016/j.conb.2005.05.005. View

17.

Banfi B, Maturana A, Jaconi S, Arnaudeau S, Laforge T, Sinha B . A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science. 1999; 287(5450):138-42. DOI: 10.1126/science.287.5450.138. View

18.

Horn R, Ding S, Gruber H . Immobilizing the moving parts of voltage-gated ion channels. J Gen Physiol. 2000; 116(3):461-76. PMC: 2233689. DOI: 10.1085/jgp.116.3.461. View

19.

Kapus A, Romanek R, Qu A, Rotstein O, Grinstein S . A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages. J Gen Physiol. 1993; 102(4):729-60. PMC: 2229171. DOI: 10.1085/jgp.102.4.729. View

20.

Miyazaki S, Igusa Y . Fertilization potential in golden hamster eggs consists of recurring hyperpolarizations. Nature. 1981; 290(5808):702-4. DOI: 10.1038/290702a0. View