Gold Nanorod Assisted Near-infrared Plasmonic Photothermal Therapy (PPTT) of Squamous Cell Carcinoma in Mice

Overview

Journal Cancer Lett

Specialty Oncology

Date 2008 Jun 11

PMID 18541363

Citations 243

Authors

Erin B Dickerson

Erik C Dreaden

Xiaohua Huang

Ivan H El-Sayed

Hunghao Chu

Sujatha Pushpanketh

John F McDonald

Mostafa A El-Sayed

Affiliations

Soon will be listed here.

Abstract

Plasmonic photothermal therapy (PPTT) is a minimally-invasive oncological treatment strategy in which photon energy is selectively administered and converted into heat sufficient to induce cellular hyperthermia. The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser. Dramatic size decreases in squamous cell carcinoma xenografts were observed for direct (P<0.0001) and intravenous (P<0.0008) administration of pegylated gold nanorods in nu/nu mice. Inhibition of average tumor growth for both delivery methods was observed over a 13-day period, with resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors.

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