Digital Light 3D Printed Bioresorbable and NIR-Responsive Devices with Photothermal and Shape-Memory Functions

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2022 Jul 27

PMID 35896948

Authors

Nevena Paunovic

Jessica Marbach

Yinyin Bao

Valentine Berger

Karina Klein

Sarah Schleich

Fergal Brian Coulter

Nicole Kleger

Andre R Studart

Daniel Franzen

Zhi Luo

Jean-Christophe Leroux

Affiliations

Soon will be listed here.

Abstract

Digital light processing (DLP) 3D printing is a promising technique for the rapid manufacturing of customized medical devices with high precision. To be successfully translated to a clinical setting, challenges in the development of suitable photopolymerizable materials have yet to be overcome. Besides biocompatibility, it is often desirable for the printed devices to be biodegradable, elastic, and with a therapeutic function. Here, a multifunctional DLP printed material system based on the composite of gold nanorods and polyester copolymer is reported. The material demonstrates robust near-infrared (NIR) responsiveness, allowing rapid and stable photothermal effect leading to the time-dependent cell death. NIR light-triggerable shape transformation is demonstrated, resulting in a facilitated insertion and expansion of DLP printed stent ex vivo. The proposed strategy opens a promising avenue for the design of multifunctional therapeutic devices based on nanoparticle-polymer composites.

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