Comparison of the Efficacies of Oral Beta-lactams in Selection of Haemophilus Influenzae Transformants with Mutated FtsI Genes

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2008 Mar 19

PMID 18347113

Citations 4

Authors

Sho Takahata

Yoshihisa Kato

Yumiko Sanbongi

Kazunori Maebashi

Takashi Ida

Affiliations

Soon will be listed here.

Abstract

Horizontal transfer of the mutated ftsI gene from beta-lactamase-nonproducing ampicillin-resistant (BLNAR) Haemophilus influenzae to a susceptible strain was examined in vitro under selection with nine oral beta-lactams (ampicillin, amoxicillin, cefprozil, cefuroxime, cefpodoxime, cefdinir, cefcapene, cefditoren, and tebipenem). Compared to the penicillins and the carbapenem, the cephalosporins showed a wide selection window for the genetic transfer.

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