Antimicrobial Surveillance of Haemophilus Influenzae in the United States During 2000-2001 Leads to Detection of Clonal Dissemination of a Beta-lactamase-negative and Ampicillin-resistant Strain

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2002 Mar 7

PMID 11880440

Citations 19

Authors

James A Karlowsky

Ian A Critchley

Renee S Blosser-Middleton

Elena A Karginova

Mark E Jones

Clyde Thornsberry

Daniel F Sahm

Affiliations

Soon will be listed here.

Abstract

A 2000-2001 U.S. Haemophilus influenzae surveillance study (n = 1,434) detected nine (0.6%) beta-lactamase-negative and ampicillin-resistant (BLNAR) isolates collected from two different hospitals. The MICs of ampicillin for all nine isolates were 4 microg/ml, with results being reproducible; and all nine isolates were susceptible to amoxicillin-clavulanate, cefuroxime, cefprozil, macrolides, and fluoroquinolones. Pulsed-field gel electrophoresis of genomic DNA following SmaI digestion demonstrated identical patterns for each of the nine isolates, suggesting intra- and interhospital dissemination of a BLNAR clone.

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