Longitudinal European Surveillance Study of Antibiotic Resistance of Haemophilus Influenzae

Overview

Journal J Antimicrob Chemother

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2006 Aug 8

PMID 16891323

Citations 21

Authors

W T M Jansen

A Verel

M Beitsma

J Verhoef

D Milatovic

Affiliations

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Abstract

Objectives: We assessed the current resistance rates of Haemophilus influenzae against beta-lactams and other agents in Europe and compared the results with those of our previously performed surveillance study.

Methods: MICs of the antibiotics were determined using broth microdilution. The penicillin-binding domain of PBP3 of beta-lactamase (BL)-negative, amoxicillin-resistant (BLNAR) isolates was sequenced.

Results: The percentage of BL-positive and BLNAR strains ranged from 0% to 17.6% and 0% to 33.9%, respectively. Compared with 1997/98 and 2002/03, the overall percentage of strains non-susceptible to amoxicillin decreased from 19.8% and 23.3%, respectively, to 16.4% in 2004/05. The percentage of BL-producing strains decreased from 11.0% and 13.7%, respectively, to 7.6%, whereas the number of BLNAR strains remained stable (8.8% and 9.6%, respectively, versus 8.8% in 2004/05). Comparison of penicillin binding protein (PBP) 3B gene sequences between BLNAR and susceptible strains revealed novel amino acid mutations.

Conclusions: In spite of large inter-regional differences, the overall resistance of H. influenzae to amoxicillin in Europe seems to decline due to a decreasing number of BL-producing strains, whereas the overall percentage of BLNAR strains seems relatively constant.

Citing Articles

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Ampicillin resistance in from COPD patients in the UK.

Maddi S, Kolsum U, Jackson S, Barraclough R, Maschera B, Simpson K Int J Chron Obstruct Pulmon Dis. 2017; 12:1507-1518.

PMID: 28579769 PMC: 5446963. DOI: 10.2147/COPD.S135338.

Clinical and molecular epidemiology of haemophilus influenzae causing invasive disease in adult patients.

Puig C, Grau I, Marti S, Tubau F, Calatayud L, Pallares R PLoS One. 2014; 9(11):e112711.

PMID: 25379704 PMC: 4224504. DOI: 10.1371/journal.pone.0112711.

Molecular epidemiology of nontypeable Haemophilus influenzae causing community-acquired pneumonia in adults.

Puig C, Calatayud L, Marti S, Tubau F, Garcia-Vidal C, Carratala J PLoS One. 2013; 8(12):e82515.

PMID: 24349303 PMC: 3862678. DOI: 10.1371/journal.pone.0082515.

Characteristics of Haemophilus influenzae invasive isolates from Portugal following routine childhood vaccination against H. influenzae serotype b (2002-2010).

Bajanca-Lavado M, Simoes A, Betencourt C, Sa-Leao R Eur J Clin Microbiol Infect Dis. 2013; 33(4):603-10.

PMID: 24154654 DOI: 10.1007/s10096-013-1994-6.