Brain Morphology and Sleep EEG in Patients with Huntington's Disease

Overview

Journal Eur Arch Psychiatry Clin Neurosci

Specialties Neurology
Psychiatry

Date 1991 Jan 1

PMID 1827599

Citations 15

Authors

M Wiegand

A A Moller

W Schreiber

C Lauer

J C Krieg

Affiliations

Soon will be listed here.

Abstract

In 12 patients with Huntington's disease, the relationship between brain morphology, nocturnal sleep EEG, and clinical variables was studied. Global cerebral atrophy did not significantly correlate with sleep parameters, whereas atrophy of the caudate nuclei was associated with reduced slow wave sleep and increased time spent awake. Several clinical parameters (e.g., anergia and thought disturbance scores of the Brief Psychiatric Rating Scale, illness duration and global clinical assessment) showed significant correlations with global cerebral atrophy. Similar studies in other neuropsychiatric disorders demonstrate associations between sleep alterations and brain morphological changes of different localizations, thus pointing to a complex relationship between both. It can be hypothesized that the caudate nuclei may be involved in sleep regulation; indirect evidence from studies with positron emission tomography (PET) point in the same direction.

Citing Articles

The sleep and circadian problems of Huntington's disease: when, why and their importance.

Voysey Z, Fazal S, Lazar A, Barker R J Neurol. 2020; 268(6):2275-2283.

PMID: 33355880 PMC: 8179890. DOI: 10.1007/s00415-020-10334-3.

Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases.

Hafycz J, Naidoo N Front Aging Neurosci. 2019; 11:140.

PMID: 31244649 PMC: 6579877. DOI: 10.3389/fnagi.2019.00140.

Sleep Disorders in Huntington's Disease.

Herzog-Krzywoszanska R, Krzywoszanski L Front Psychiatry. 2019; 10:221.

PMID: 31031659 PMC: 6474183. DOI: 10.3389/fpsyt.2019.00221.

Sleep Physiology Alterations Precede Plethoric Phenotypic Changes in R6/1 Huntington's Disease Mice.

Lebreton F, Cayzac S, Pietropaolo S, Jeantet Y, Cho Y PLoS One. 2015; 10(5):e0126972.

PMID: 25966356 PMC: 4428700. DOI: 10.1371/journal.pone.0126972.

Polysomnographic Findings and Clinical Correlates in Huntington Disease: A Cross-Sectional Cohort Study.

Piano C, Losurdo A, Della Marca G, Solito M, Calandra-Buonaura G, Provini F Sleep. 2015; 38(9):1489-95.

PMID: 25845698 PMC: 4531417. DOI: 10.5665/sleep.4996.

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