Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2019 Jun 28

PMID 31244649

Citations 13

Authors

Jennifer M Hafycz

Nirinjini N Naidoo

Affiliations

Soon will be listed here.

Abstract

Many neurodegenerative diseases manifest in an overall aged population, the pathology of which is hallmarked by abnormal protein aggregation. It is known that across aging, sleep quality becomes less efficient and protein homeostatic regulatory mechanisms deteriorate. There is a known relationship between extended wakefulness and poorly consolidated sleep and an increase in cellular stress. In an aged population, when sleep is chronically poor, and proteostatic regulatory mechanisms are less efficient, the cell is inundated with misfolded proteins and suffers a collapse in homeostasis. In this review article, we explore the interplay between aging, sleep quality, and proteostasis and how these processes are implicated in the development and progression of neurodegenerative diseases like Alzheimer's disease (AD). We also present data suggesting that reducing cellular stress and improving proteostasis and sleep quality could serve as potential therapeutic solutions for the prevention or delay in the progression of these diseases.

Citing Articles

Long Sleep Duration, Cognitive Performance, and the Moderating Role of Depression: A Cross-Sectional Analysis in the Framingham Heart Study.

Young V, Bernal R, Baril A, Zeynoun J, Wiedner C, Gaona C medRxiv. 2024; .

PMID: 39677456 PMC: 11643162. DOI: 10.1101/2024.12.02.24318350.

Sleep and Oxidative Stress: Current Perspectives on the Role of NRF2.

Davinelli S, Medoro A, Savino R, Scapagnini G Cell Mol Neurobiol. 2024; 44(1):52.

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TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity of neuroactivity in prefrontal cortex.

Zhang H, Chen C, Zhang E, Huang X iScience. 2024; 27(4):109522.

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Biology of Stress Responses in Aging.

Maragkakis M, Malla S, Hatzoglou M, Trifunovic A, Glick A, Finkel T Aging Biol. 2024; 1.

PMID: 38500537 PMC: 10947073. DOI: 10.59368/agingbio.20230001.

Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease.

Morrone C, Raghuraman R, Hussaini S, Yu W Mol Neurodegener. 2023; 18(1):27.

PMID: 37085942 PMC: 10119020. DOI: 10.1186/s13024-023-00617-4.

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