VEGF-C Induced Angiogenesis Preferentially Occurs at a Distance from Lymphangiogenesis

Overview

Journal Cardiovasc Res

Specialty Cardiology & Vascular Diseases

Date 2007 Dec 11

PMID 18065770

Citations 43

Authors

Andrew V Benest

Steven J Harper

Seppo Yla Herttuala

Kari Alitalo

David O Bates

Affiliations

Soon will be listed here.

Abstract

Aims: Vascular endothelial growth factor-C (VEGF-C) has been shown to stimulate both angiogenesis and lymphangiogenesis in some but not all models where VEGF-C is over-expressed. Our aim was to investigate the interaction between lymphangiogenesis and angiogenesis in adult tissues regulated by VEGF-C and identify evidence of polarized growth of lymphatics driven by specialized cells at the tip of the growing sprout.

Methods And Results: We used an adult model of lymphangiogenesis in the rat mesentery. The angiogenic effect of VEGF-C was markedly attenuated in the presence of a growing lymphatic network. Furthermore, we show that this growth of lymphatic vessels can occur both by recruitment of isolated lymphatic islands to a connected network and by filopodial sprouting. The latter is independent of polarized tip cell differentiation that can be generated all along lymphatic capillaries, independently of the proliferation status of the lymphatic endothelial cells.

Conclusion: These results both demonstrate a dependence of VEGF-C-mediated angiogenesis on lymphatic vascular networks and indicate that the mechanism of VEGF-C-mediated lymphangiogenesis is different from that of classical angiogenic mechanisms.

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