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Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology

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Journal Front Physiol
Date 2021 Nov 19
PMID 34795596
Citations 4
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Abstract

The lymphatic system is a vascular system comprising modified lymphatic endothelial cells, lymph nodes and other lymphoid organs. The system has diverse, but critical functions in both physiology and pathology, and forms an interface between the blood vascular and immune system. It is increasingly evident that remodelling of the lymphatic system occurs alongside remodelling of the blood microvascular system, which is now considered a hallmark of most pathological conditions as well as being critical for normal development. Much attention has focussed on how the blood endothelium undergoes phenotypic switching in development and disease, resulting in over two decades of research to probe the mechanisms underlying the resulting heterogeneity. The lymphatic system has received less attention, and consequently there are fewer descriptions of functional and molecular heterogeneity, but differential transcription factor activity is likely an important control mechanism. Here we introduce and discuss significant transcription factors of relevance to coordinating cellular responses during lymphatic remodelling as the lymphatic endothelium dynamically changes from quiescence to actively remodelling.

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References
1.
Schoppmann S, Fenzl A, Schindl M, Bachleitner-Hofmann T, Nagy K, Gnant M . Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer. Breast Cancer Res Treat. 2006; 99(2):135-41. DOI: 10.1007/s10549-006-9190-3. View

2.
Trincot C, Caron K . Lymphatic Function and Dysfunction in the Context of Sex Differences. ACS Pharmacol Transl Sci. 2020; 2(5):311-324. PMC: 7089000. DOI: 10.1021/acsptsci.9b00051. View

3.
Suchting S, Freitas C, le Noble F, Benedito R, Breant C, Duarte A . The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A. 2007; 104(9):3225-30. PMC: 1805603. DOI: 10.1073/pnas.0611177104. View

4.
Boardman K, Swartz M . Interstitial flow as a guide for lymphangiogenesis. Circ Res. 2003; 92(7):801-8. DOI: 10.1161/01.RES.0000065621.69843.49. View

5.
Dieterich L, Klein S, Mathelier A, Sliwa-Primorac A, Ma Q, Hong Y . DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium. Cell Rep. 2015; 13(7):1493-1504. DOI: 10.1016/j.celrep.2015.10.002. View