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Chromosomal Rearrangements and MicroRNAs: a New Cancer Link with Clinical Implications

Overview
Journal J Clin Invest
Specialty General Medicine
Date 2007 Aug 3
PMID 17671640
Citations 66
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Abstract

There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.

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