The NcRNA-AURKA Interaction in Hepatocellular Carcinoma: Insights into Oncogenic Pathways, Therapeutic Opportunities, and Future Challenges

Overview

Journal Life (Basel)

Specialty Biology

Date 2024 Nov 27

PMID 39598228

Authors

Clarissa Joy C Garcia

Luca Grisetti

Claudio Tiribelli

Devis Pascut

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) represents a major public health concern and ranks among the leading cancer-related mortalities globally. Due to the frequent late-stage diagnosis of HCC, therapeutic options remain limited. Emerging evidence highlights the critical role of non-coding RNAs (ncRNAs) in the regulation of Aurora kinase A (AURKA), one of the key hub genes involved in several key cancer pathways. Indeed, the dysregulated interaction between ncRNAs and AURKA contributes to tumor development, progression, and therapeutic resistance. This review delves into the interplay between ncRNAs and AURKA and their role in hepatocarcinogenesis. Recent findings underscore the involvement of the ncRNAs and AURKA axis in tumor development and progression. Furthermore, this review also discusses the clinical significance of targeting ncRNA-AURKA axes, offering new perspectives that could lead to innovative therapeutic strategies aimed at improving outcomes for HCC patients.

References

Ballabeni A, Melixetian M, Zamponi R, Masiero L, Marinoni F, Helin K . Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J. 2004; 23(15):3122-32. PMC: 514931. DOI: 10.1038/sj.emboj.7600314. View

Macfarlane L, Murphy P . MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics. 2011; 11(7):537-61. PMC: 3048316. DOI: 10.2174/138920210793175895. View

Shen Z, Chen Y, Huang G, Zhu X, Wang R, Chen L . Aurora-a confers radioresistance in human hepatocellular carcinoma by activating NF-κB signaling pathway. BMC Cancer. 2019; 19(1):1075. PMC: 6842208. DOI: 10.1186/s12885-019-6312-y. View

Ganne-Carrie N, Nahon P . Hepatocellular carcinoma in the setting of alcohol-related liver disease. J Hepatol. 2019; 70(2):284-293. DOI: 10.1016/j.jhep.2018.10.008. View

Glover D, Alphey L, Axton J, Cheshire A, Dalby B, Freeman M . Mitosis in Drosophila development. J Cell Sci Suppl. 1989; 12:277-91. DOI: 10.1242/jcs.1989.supplement_12.22. View

Romeo M, Dallio M, Scognamiglio F, Ventriglia L, Cipullo M, Coppola A . Role of Non-Coding RNAs in Hepatocellular Carcinoma Progression: From Classic to Novel Clinicopathogenetic Implications. Cancers (Basel). 2023; 15(21). PMC: 10647270. DOI: 10.3390/cancers15215178. View

Qiu J, Lin X, Tang X, Zheng T, Lin Y, Hua K . Exosomal Metastasis‑Associated Lung Adenocarcinoma Transcript 1 Promotes Angiogenesis and Predicts Poor Prognosis in Epithelial Ovarian Cancer. Int J Biol Sci. 2018; 14(14):1960-1973. PMC: 6299373. DOI: 10.7150/ijbs.28048. View

Llovet J, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc J . Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008; 359(4):378-90. DOI: 10.1056/NEJMoa0708857. View

Nikonova A, Astsaturov I, Serebriiskii I, Dunbrack Jr R, Golemis E . Aurora A kinase (AURKA) in normal and pathological cell division. Cell Mol Life Sci. 2012; 70(4):661-87. PMC: 3607959. DOI: 10.1007/s00018-012-1073-7. View

10.

Bertolin G, Tramier M . Insights into the non-mitotic functions of Aurora kinase A: more than just cell division. Cell Mol Life Sci. 2019; 77(6):1031-1047. PMC: 11104877. DOI: 10.1007/s00018-019-03310-2. View

11.

Chen C, Song G, Xiang J, Zhang H, Zhao S, Zhan Y . AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma. Biochem Biophys Res Commun. 2017; 486(2):514-520. DOI: 10.1016/j.bbrc.2017.03.075. View

12.

Hu Y, Dingerdissen H, Gupta S, Kahsay R, Shanker V, Wan Q . Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis. Comput Biol Med. 2018; 103:183-197. PMC: 6279243. DOI: 10.1016/j.compbiomed.2018.10.021. View

13.

Li S, Ma F, Jiang K, Shan H, Shi M, Chen B . Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 promotes lung adenocarcinoma by directly interacting with specificity protein 1. Cancer Sci. 2018; 109(5):1346-1356. PMC: 5980339. DOI: 10.1111/cas.13587. View

14.

Yau T, Park J, Finn R, Cheng A, Mathurin P, Edeline J . Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial. Lancet Oncol. 2021; 23(1):77-90. DOI: 10.1016/S1470-2045(21)00604-5. View

15.

Lei H, Gao Y, Xu X . LncRNA TUG1 influences papillary thyroid cancer cell proliferation, migration and EMT formation through targeting miR-145. Acta Biochim Biophys Sin (Shanghai). 2017; 49(7):588-597. DOI: 10.1093/abbs/gmx047. View

16.

Niu Z, Wang W, Dong X, Tian L . Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma. World J Gastroenterol. 2020; 26(29):4240-4260. PMC: 7422540. DOI: 10.3748/wjg.v26.i29.4240. View

17.

Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T . Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002; 12(9):735-9. DOI: 10.1016/s0960-9822(02)00809-6. View

18.

Singal A, Lampertico P, Nahon P . Epidemiology and surveillance for hepatocellular carcinoma: New trends. J Hepatol. 2020; 72(2):250-261. PMC: 6986771. DOI: 10.1016/j.jhep.2019.08.025. View

19.

Lam S, Shi Z, Ip C, Wong C, Wong A . Environmental-relevant bisphenol A exposure promotes ovarian cancer stemness by regulating microRNA biogenesis. J Cell Mol Med. 2023; 27(18):2792-2803. PMC: 10494296. DOI: 10.1111/jcmm.17920. View

20.

Shen H, Zhang D, Xiao P, Qu B, Sun Y . E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA. Cancer Gene Ther. 2023; 30(7):1007-1017. PMC: 10353940. DOI: 10.1038/s41417-023-00607-0. View