Non-coding RNAs in Cancers with Chromosomal Rearrangements: the Signatures, Causes, Functions and Implications

Overview

Journal J Mol Cell Biol

Publisher Oxford University Press

Specialty Molecular Biology

Date 2019 Jul 31

PMID 31361891

Citations 12

Authors

Cai Han

Lin-Yu Sun

Wen-Tao Wang

Yu-Meng Sun

Yue-Qin Chen

Affiliations

Soon will be listed here.

Abstract

Chromosomal translocation leads to the juxtaposition of two otherwise separate DNA loci, which could result in gene fusion. These rearrangements at the DNA level are catastrophic events and often have causal roles in tumorigenesis. The oncogenic DNA messages are transferred to RNA molecules, which are in most cases translated into cancerous fusion proteins. Gene expression programs and signaling pathways are altered in these cytogenetically abnormal contexts. Notably, non-coding RNAs have attracted increasing attention and are believed to be tightly associated with chromosome-rearranged cancers. These RNAs not only function as modulators in downstream pathways but also directly affect chromosomal translocation or the associated products. This review summarizes recent research advances on the relationship between non-coding RNAs and chromosomal translocations and on diverse functions of non-coding RNAs in cancers with chromosomal rearrangements.

Citing Articles

The landscape of fusion transcripts in plants: a new insight into genome complexity.

Chitkara P, Singh A, Gangwar R, Bhardwaj R, Zahra S, Arora S BMC Plant Biol. 2024; 24(1):1162.

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PFusionDB: a comprehensive database of plant-specific fusion transcripts.

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Identification of a novel RAB6A::TOP2A fusion in acute non-promyelocytic leukemia harboring t(11;17)(q13;q21) translocation.

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Cancer fusion transcripts with human non-coding RNAs.

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Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer.

Sanchez-Marin D, Silva-Cazares M, Porras-Reyes F, Garcia-Roman R, Campos-Parra A Genes Dis. 2024; 11(3):101136.

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