MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2007 Jul 12

PMID 17622355

Citations 325

Authors

Eniko Sonkoly

Tianling Wei

Peter C J Janson

Annika Saaf

Lena Lundeberg

Maria Tengvall-Linder

Gunnar Norstedt

Harri Alenius

Bernhard Homey

Annika Scheynius

Mona Stahle

Andor Pivarcsi

Affiliations

Soon will be listed here.

Abstract

MicroRNAs are a recently discovered class of posttranscriptional regulators of gene expression with critical functions in health and disease. Psoriasis is the most prevalent chronic inflammatory skin disease in adults, with a substantial negative impact on the patients' quality of life. Here we show for the first time that psoriasis-affected skin has a specific microRNA expression profile when compared with healthy human skin or with another chronic inflammatory skin disease, atopic eczema. Among the psoriasis-specific microRNAs, we identified leukocyte-derived microRNAs and one keratinocyte-derived microRNA, miR-203. In a panel of 21 different human organs and tissues, miR-203 showed a highly skin-specific expression profile. Among the cellular constituents of the skin, it was exclusively expressed by keratinocytes. The up-regulation of miR-203 in psoriatic plaques was concurrent with the down-regulation of an evolutionary conserved target of miR-203, suppressor of cytokine signaling 3 (SOCS-3), which is involved in inflammatory responses and keratinocyte functions. Our results suggest that microRNA deregulation is involved in the pathogenesis of psoriasis and contributes to the dysfunction of the cross talk between resident and infiltrating cells. Taken together, a new layer of regulatory mechanisms is involved in the pathogenesis of chronic inflammatory skin diseases.

Citing Articles

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