The Role of Epigenetic Factors in the Pathogenesis of Psoriasis

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Apr 13

PMID 38612637

Authors

Joanna Olejnik-Wojciechowska

Dominika Boboryko

Aleksandra Wiktoria Bratborska

Klaudia Rusinska

Piotr Ostrowski

Magdalena Baranowska

Andrzej Pawlik

Affiliations

Soon will be listed here.

Abstract

Psoriasis is a chronic inflammatory skin disease, the prevalence of which is increasing. Genetic, genomic, and epigenetic changes play a significant role in the pathogenesis of psoriasis. This review summarizes the impact of epigenetics on the development of psoriasis and highlights challenges for the future. The development of epigenetics provides a basis for the search for genetic markers associated with the major histocompatibility complex. Genome-wide association studies have made it possible to link psoriasis to genes and therefore to epigenetics. The acquired knowledge may in the future serve as a solid foundation for developing newer, increasingly effective methods of treating psoriasis. In this narrative review, we discuss the role of epigenetic factors in the pathogenesis of psoriasis.

Citing Articles

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