Evaluation of Methods to Identify the Klebsiella Pneumoniae Carbapenemase in Enterobacteriaceae

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2007 Jun 22

PMID 17581941

Citations 145

Authors

K F ANDERSON

D R Lonsway

J K Rasheed

J Biddle

B Jensen

L K McDougal

R B Carey

A Thompson

S Stocker

B Limbago

J B Patel

Affiliations

Soon will be listed here.

Abstract

The Klebsiella pneumoniae carbapenem (KPC) beta-lactamase occurs in Enterobacteriaceae and can confer resistance to all beta-lactam agents including carbapenems. The enzyme may confer low-level carbapenem resistance, and the failure of susceptibility methods to identify this resistance has been reported. Automated and nonautomated methods for carbapenem susceptibility were evaluated for identification of KPC-mediated resistance. Ertapenem was a more sensitive indicator of KPC resistance than meropenem and imipenem independently of the method used. Carbapenemase production could be confirmed with the modified Hodge test.

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