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Detection of KPC Carbapenem-hydrolyzing Enzymes in Enterobacter Spp. from Brooklyn, New York

Overview
Specialty Pharmacology
Date 2005 Jan 28
PMID 15673765
Citations 43
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Abstract

Enterobacter spp. are rarely resistant to carbapenems. In this report, one Enterobacter sp. isolate possessed bla(KPC-3) and two possessed bla(KPC-2). For all three strains, the imipenem MICs were dependent on the inoculum and testing method; two were reported by the clinical laboratories to be carbapenem susceptible. Improved detection methods will be necessary to identify these enzymes.

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References
1.
Bornet C, Davin-Regli A, Bosi C, Pages J, Bollet C . Imipenem resistance of enterobacter aerogenes mediated by outer membrane permeability. J Clin Microbiol. 2000; 38(3):1048-52. PMC: 86335. DOI: 10.1128/JCM.38.3.1048-1052.2000. View

2.
Weber D, Raasch R, Rutala W . Nosocomial infections in the ICU: the growing importance of antibiotic-resistant pathogens. Chest. 1999; 115(3 Suppl):34S-41S. DOI: 10.1378/chest.115.suppl_1.34s. View

3.
Quale J, Landman D, Bradford P, Visalli M, Ravishankar J, Flores C . Molecular epidemiology of a citywide outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae infection. Clin Infect Dis. 2002; 35(7):834-41. DOI: 10.1086/342577. View

4.
Yigit H, Anderson G, Biddle J, Steward C, Rasheed J, Valera L . Carbapenem resistance in a clinical isolate of Enterobacter aerogenes is associated with decreased expression of OmpF and OmpC porin analogs. Antimicrob Agents Chemother. 2002; 46(12):3817-22. PMC: 132746. DOI: 10.1128/AAC.46.12.3817-3822.2002. View

5.
. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 to June 2002, issued August 2002. Am J Infect Control. 2002; 30(8):458-75. DOI: 10.1067/mic.2002.130032. View