H Pylori Exist in the Gallbladder Mucosa of Patients with Chronic Cholecystitis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2007 Apr 28

PMID 17461457

Citations 14

Authors

Dong-Feng Chen

Lu Hu

Ping Yi

Wei-Wen Liu

Dian-Chun Fang

Hong Cao

Affiliations

Soon will be listed here.

Abstract

Aim: To study whether H pylori locate in the gallbladder mucosa of patients with chronic cholecystitis.

Methods: Using Warthy-Starry (W-S) silver stain and immunohistochemistry stain with anti-H pylori antibodies, we screened paraffin specimens in 524 cases of cholecystitis. H pylori urease gene A (HPUA) and H pylori urease gene B (HPUB) were analyzed by polymerase chain reaction (PCR) in the fresh tissue specimens from 81 cases of cholecystitis.

Results: H pylori-like bacteria were found in 13.55% of the gallbladders of the cholecystitis patients using W-S stain. Meanwhile, bacteria positive for H pylori antibodies were also found in 7.1% of the gallbladders of patients with cholecystitis by immunohistochemistry. Of 81 gallbladders, 11 were positive for both HPUA and HPUB, 4 were positive for HPUA only and 7 were positive for HPUB only.

Conclusion: H pylori exist in the gallbladders of patients with chronic cholecystitis.

Citing Articles

The link between infection and gallbladder and biliary tract diseases: A review.

Lim K, Lee A, Jiang X, Teng T, Shelat V Ann Hepatobiliary Pancreat Surg. 2023; 27(3):241-250.

PMID: 37357161 PMC: 10472116. DOI: 10.14701/ahbps.22-056.

Association of human gut microbiota with rare diseases: A close peep through.

Roy S, Nag S, Saini A, Choudhury L Intractable Rare Dis Res. 2022; 11(2):52-62.

PMID: 35702576 PMC: 9161125. DOI: 10.5582/irdr.2022.01025.

The Relationship between Infection of the Gallbladder and Chronic Cholecystitis and Cholelithiasis: A Systematic Review and Meta-Analysis.

Wang L, Chen J, Jiang W, Cen L, Pan J, Yu C Can J Gastroenterol Hepatol. 2021; 2021:8886085.

PMID: 33505946 PMC: 7806380. DOI: 10.1155/2021/8886085.

Unusual Manifestation of Live , and in the Gallbladder with Cholecystitis.

Backert S, Tegtmeyer N, Oyarzabal O, Osman D, Rohde M, Grutzmann R Int J Mol Sci. 2018; 19(7).

PMID: 29933576 PMC: 6073424. DOI: 10.3390/ijms19071826.

Dietary PUFA Increase Apoptosis in Stomach of Patients with Dyspeptic Symptoms and Infected with H. pylori.

Sharifi R, Nouri M, Eidi A, Noormohammadi Z, Dolatkhah H, Shirmohammadi M Lipids. 2017; 52(6):549-558.

PMID: 28493185 DOI: 10.1007/s11745-017-4257-y.

References

Silva C, Pereira-Lima J, Oliveira A, Guerra J, Marques D, Sarmanho L . Association of the presence of Helicobacter in gallbladder tissue with cholelithiasis and cholecystitis. J Clin Microbiol. 2003; 41(12):5615-8. PMC: 309000. DOI: 10.1128/JCM.41.12.5615-5618.2003. View

Messini F . [Helicobacter pylori and hepatobiliary diseases]. Clin Ter. 2003; 154(1):55-6. View

Arnaout A, Abbas S, Shousha S . Helicobacter pylori is not identified in areas of gastric metaplasia of gall bladder. J Pathol. 1990; 160(4):333-4. DOI: 10.1002/path.1711600410. View

Caldwell M, McDermott M, Jazrawi S, ODowd G, Byrne P, Walsh T . Helicobacter pylori infection increases following cholecystectomy. Ir J Med Sci. 1995; 164(1):52-5. DOI: 10.1007/BF02968117. View

Kawaguchi M, Saito T, Ohno H, Midorikawa S, Sanji T, Handa Y . Bacteria closely resembling Helicobacter pylori detected immunohistologically and genetically in resected gallbladder mucosa. J Gastroenterol. 1996; 31(2):294-8. DOI: 10.1007/BF02389534. View

Osadchuk M, Geraskina T . [Chronic cholecystitis--some lithogenic aspects]. Ter Arkh. 1997; 69(2):27-30. View

Apostolov E, Abu Al-Soud W, Nilsson I, Kornilovska I, Usenko V, Lyzogubov V . Helicobacter pylori and other Helicobacter species in gallbladder and liver of patients with chronic cholecystitis detected by immunological and molecular methods. Scand J Gastroenterol. 2005; 40(1):96-102. DOI: 10.1080/00365520410009546. View

Pradhan S, Dali S . Relation between gallbladder neoplasm and Helicobacter hepaticus infection. Kathmandu Univ Med J (KUMJ). 2006; 2(4):331-5. View

Randi G, Franceschi S, La Vecchia C . Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006; 118(7):1591-602. DOI: 10.1002/ijc.21683. View

10.

Vere C, Cazacu S, Comanescu V, Mogoanta L, Rogoveanu I, Ciurea T . Endoscopical and histological features in bile reflux gastritis. Rom J Morphol Embryol. 2006; 46(4):269-74. View

11.

Andersen L . New Helicobacter species in humans. Dig Dis. 2001; 19(2):112-5. DOI: 10.1159/000050664. View

12.

Monstein H, Jonsson Y, Zdolsek J, Svanvik J . Identification of Helicobacter pylori DNA in human cholesterol gallstones. Scand J Gastroenterol. 2002; 37(1):112-9. DOI: 10.1080/003655202753387455. View

13.

Leong R, Sung J . Review article: Helicobacter species and hepatobiliary diseases. Aliment Pharmacol Ther. 2002; 16(6):1037-45. DOI: 10.1046/j.1365-2036.2002.01282.x. View

14.

Bulajic M, Maisonneuve P, Schneider-Brachert W, Muller P, Reischl U, Stimec B . Helicobacter pylori and the risk of benign and malignant biliary tract disease. Cancer. 2002; 95(9):1946-53. DOI: 10.1002/cncr.10893. View

15.

Fallone C, Tran S, Semret M, Discepola F, Behr M, Barkun A . Helicobacter DNA in bile: correlation with hepato-biliary diseases. Aliment Pharmacol Ther. 2003; 17(3):453-8. DOI: 10.1046/j.1365-2036.2003.01424.x. View

16.

Farinati F, Cardin R, Russo V, Busatto G, Franco M, Rugge M . Helicobacter pylori CagA status, mucosal oxidative damage and gastritis phenotype: a potential pathway to cancer?. Helicobacter. 2003; 8(3):227-34. DOI: 10.1046/j.1523-5378.2003.00149.x. View

17.

Dore M, Sepulveda A, Bacciu P, Blasi F, Simula L, Marras L . Detection of Chlamydiae pneumoniae but not Helicobacter pylori DNA in atherosclerosis plaques. Dig Dis Sci. 2003; 48(5):945-51. DOI: 10.1023/a:1023059815117. View

18.

Tsukanov V, Grishchenko N . [Association of Helicobacter pylori with chronic cholecystitis]. Eksp Klin Gastroenterol. 2004; (6):80-2. View