Detection of Chlamydiae Pneumoniae but Not Helicobacter Pylori DNA in Atherosclerosis Plaques

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2003 May 30

PMID 12772795

Citations 8

Authors

Maria P Dore

Antonia R Sepulveda

Piero P Bacciu

Francesco Blasi

Luigi Simula

Lea Marras

Davide Piccolo

Giovanni B Cherchi

David Y Graham

Giuseppe Realdi

Affiliations

Soon will be listed here.

Abstract

Chronic infections have been associated with cardiovascular disease. We used bacterial culture, polymerase chain reaction (PCR), and immunohistochemical staining with anti-vacA and anticagA antibodies to search for Helicobacter pylori and Chlamydiae pneumoniae in atherosclerotic plaques obtained at endarterectomy. Serum IgG antibodies to H. pylori and C. pneumoniae were also determined. Thirty-two patients were enrolled. Anti-H. pylori and anti-C. pneumoniae IgG were present in 72% and 81%, respectively. Culture and PCR for H. pylori of vessel walls and plaques were negative. Atherosclerotic plaque and normal vessel sections from H. pylori-negative and- positive patients showed reactivity with anti-vacA and anti-cagA antibodies. C. pneumoniae DNA was amplified in three atherosclerotic lesions. These findings suggest that the association between H. pylori infection and atherosclerosis does not result from continuing direct effects of H. pylori antigens in the vessel walls. Antigens within vessel atherosclerotic plaques cross-react with H. pylori virulence factors and could act as cofactors in determining instability for the atherosclerotic plaques.

Citing Articles

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Dore M, Saba P, Tomassini G, Niolu C, Monaco M, Pes G J Clin Med. 2022; 11(9).

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The Elderly with Glucose-6-Phosphate Dehydrogenase Deficiency are More Susceptible to Cardiovascular Disease.

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Tissue transglutaminase activity in human gastric mucosa according to Helicobacter pylori infection.

Dore M, Pes G, Errigo A, Manca A, Realdi G Exp Biol Med (Maywood). 2018; 243(15-16):1161-1164.

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SNP-SNP Interaction between TLR4 and MyD88 in Susceptibility to Coronary Artery Disease in the Chinese Han Population.

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Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes.

Delitala A, Pes G, Malaty H, Pisanu G, Delitala G, Dore M J Diabetes Res. 2016; 2016:7347065.

PMID: 26824048 PMC: 4707366. DOI: 10.1155/2016/7347065.

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