Reactome: a Knowledge Base of Biologic Pathways and Processes

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2007 Mar 21

PMID 17367534

Citations 299

Authors

Imre Vastrik

Peter DEustachio

Esther Schmidt

Geeta Joshi-Tope

Gopal Gopinath

David Croft

Bernard de Bono

Marc Gillespie

Bijay Jassal

Suzanna Lewis

Lisa Matthews

Guanming Wu

Ewan Birney

Lincoln Stein

Affiliations

Soon will be listed here.

Abstract

Reactome http://www.reactome.org, an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae. Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.

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