Patrick C Bradshaw
Overview
Explore the profile of Patrick C Bradshaw including associated specialties, affiliations and a list of published articles.
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37
Citations
1096
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Recent Articles
1.
Bradshaw P, Aldridge J, Jamerson L, McNeal C, Pearson A, Frasier C
Mol Neurobiol
. 2024 Nov;
PMID: 39557801
Cardiolipin (CL) is an essential phospholipid that supports the functions of mitochondrial membrane transporters and oxidative phosphorylation complexes. Due to the high level of fatty acyl chain unsaturation, CL is...
2.
Jamerson L, Bradshaw P
Antioxidants (Basel)
. 2024 Jul;
13(7).
PMID: 39061889
Dietary restriction (DR) protocols frequently employ intermittent fasting. Following a period of fasting, meal consumption increases lipogenic gene expression, including that of NADPH-generating enzymes that fuel lipogenesis in white adipose...
3.
4.
Peters J, Peters M, Bradshaw P
MicroPubl Biol
. 2023 Jun;
2023.
PMID: 37325193
Nicotinamide riboside (NR), a form of vitamin B3 and a nicotinamide adenine dinucleotide (NAD ) precursor, has been shown to activate the mitochondrial unfolded protein response (UPR ) and extend...
5.
Curtis W, Seeds W, Mattson M, Bradshaw P
Cells
. 2022 Aug;
11(15).
PMID: 35954260
Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases reactive oxygen species (ROS) levels and lowers ATP...
6.
Bradshaw P
Antioxidants (Basel)
. 2021 Apr;
10(4).
PMID: 33917812
Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan extending calorie restriction (CR) decreases...
7.
Griffin J, Bradshaw P
Protein J
. 2021 Feb;
40(2):175-183.
PMID: 33566321
Alzheimer's disease (AD) patients could benefit from a more effective treatment than the current FDA-approved options. Because amyloid-beta (Aβ) is thought to play a central role in AD pathogenesis, many...
8.
Bradshaw P, Seeds W, Miller A, Mahajan V, Curtis W
Oxid Med Cell Longev
. 2020 Oct;
2020:6401341.
PMID: 33014275
Human SARS-CoV-2 infection is characterized by a high mortality rate due to some patients developing a large innate immune response associated with a cytokine storm and acute respiratory distress syndrome...
9.
Veech R, King M, Pawlosky R, Bradshaw P, Curtis W
FASEB J
. 2019 Nov;
33(12):13126-13130.
PMID: 31690124
Cell membrane potential and inorganic ion distributions are currently viewed from a kinetic electric paradigm, which ignores thermodynamics. The resting membrane potential is viewed as a diffusion potential. The 9...
10.
Griffin J, Bradshaw P
Theor Biol Med Model
. 2019 Aug;
16(1):11.
PMID: 31366360
Background: After proteolysis, the majority of released amino acids from dietary protein are transported to the liver for gluconeogenesis or to peripheral tissues where they are used for protein synthesis...