The Role of Mitochondria in Vascular Calcification

Overview

Journal J Transl Int Med

Publisher Sciendo

Specialty General Medicine

Date 2020 Sep 28

PMID 32983930

Citations 14

Authors

Pengbo Wang

Naijin Zhang

Boquan Wu

Shaojun Wu

Ying Zhang

Yingxian Sun

Affiliations

Soon will be listed here.

Abstract

Vascular calcification (VC) was defined as the ectopic deposition of calcium-phosphorus complexes on the blood vessel walls. It was a process involving multiple factors and mechanisms, covering the phenotype transition of vascular smooth muscle cells (VSMCs) and release of microvesicles. It was a common end-stage alteration of chronic diseases such as cardiovascular disease and chronic kidney disease. Increasing evidence indicates that mitochondria were involved in the development of VC. Mitochondria provided energy to cells, maintained the stability of cell functions, and participated in a variety of biological behavior. Oxidative stress, autophagy, apoptosis, and mitochondrial DNA (mtDNA) damage could affect the development of VSMCs calcification by alteration of mitochondrial function. This article reviewed the mechanism of calcification and the role of mitochondria in VC, aiming to raise a novel insight into drug development and clinical treatment.

Citing Articles

Reduction of Mitochondrial Calcium Overload via MKT077-Induced Inhibition of Glucose-Regulated Protein 75 Alleviates Skeletal Muscle Pathology in Dystrophin-Deficient Mice.

Dubinin M, Stepanova A, Mikheeva I, Igoshkina A, Cherepanova A, Talanov E Int J Mol Sci. 2024; 25(18).

PMID: 39337383 PMC: 11432509. DOI: 10.3390/ijms25189892.

Inflammation-associated ectopic mineralization.

Song J, Liu M, Ma Y, Wan Q, Li J, Diao X Fundam Res. 2024; 3(6):1025-1038.

PMID: 38933004 PMC: 11197766. DOI: 10.1016/j.fmre.2022.04.020.

Osteopontin/SPP1: a potential mediator between immune cells and vascular calcification.

Zhao Y, Huang Z, Gao L, Ma H, Chang R Front Immunol. 2024; 15:1395596.

PMID: 38919629 PMC: 11196619. DOI: 10.3389/fimmu.2024.1395596.

Influence of DNA Methylation on Vascular Smooth Muscle Cell Phenotypic Switching.

Yorn C, Kim H, Jeong K Int J Mol Sci. 2024; 25(6).

PMID: 38542110 PMC: 10969885. DOI: 10.3390/ijms25063136.

Role of PTEN-Induced Protein Kinase 1 as a Mitochondrial Dysfunction Regulator in Cardiovascular Disease Pathogenesis.

Gwon J, Lee S Vasc Specialist Int. 2024; 40:9.

PMID: 38486493 PMC: 10940882. DOI: 10.5758/vsi.230116.

References

Giovannucci E, Liu Y, Hollis B, Rimm E . 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008; 168(11):1174-80. PMC: 3719391. DOI: 10.1001/archinte.168.11.1174. View

Bleier L, Drose S . Superoxide generation by complex III: from mechanistic rationales to functional consequences. Biochim Biophys Acta. 2012; 1827(11-12):1320-31. DOI: 10.1016/j.bbabio.2012.12.002. View

Kujoth G, Bradshaw P, Haroon S, Prolla T . The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet. 2007; 3(2):e24. PMC: 1802824. DOI: 10.1371/journal.pgen.0030024. View

KERR J, Wyllie A, Currie A . Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972; 26(4):239-57. PMC: 2008650. DOI: 10.1038/bjc.1972.33. View

Chen N, Moe S . Vascular calcification: pathophysiology and risk factors. Curr Hypertens Rep. 2012; 14(3):228-37. PMC: 3959826. DOI: 10.1007/s11906-012-0265-8. View

Mo S, Hong J, Chen X, Han F, Ni Y, Zheng Y . VEGF-mediated NF-κB activation protects PC12 cells from damage induced by hypoxia. Neurosci Lett. 2015; 610:54-9. DOI: 10.1016/j.neulet.2015.10.051. View

Schriner S, Linford N, Martin G, Treuting P, Ogburn C, Emond M . Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005; 308(5730):1909-11. DOI: 10.1126/science.1106653. View

Ma W, Sun X, Wang Y, Zhu Y, Han X, Liu N . Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis. Mol Cell Endocrinol. 2018; 479:39-53. DOI: 10.1016/j.mce.2018.08.012. View

Michiels C, Fransen P, De Munck D, De Meyer G, Martinet W . Defective autophagy in vascular smooth muscle cells alters contractility and Ca²⁺ homeostasis in mice. Am J Physiol Heart Circ Physiol. 2015; 308(6):H557-67. DOI: 10.1152/ajpheart.00659.2014. View

10.

Khandwala K, Ahmed A, Sheikh T . MELAS: A Complex and Challenging Diagnosis. J Coll Physicians Surg Pak. 2018; 28(3):S46-S48. DOI: 10.29271/jcpsp.2018.03.S46. View

11.

Zhang W, Li Y, Ding H, Du Y, Wang L . Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway. Ren Fail. 2016; 38(7):1099-106. DOI: 10.1080/0886022X.2016.1194143. View

12.

Shroff R, McNair R, Figg N, Skepper J, Schurgers L, Gupta A . Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation. 2008; 118(17):1748-57. DOI: 10.1161/CIRCULATIONAHA.108.783738. View

13.

Yahagi K, Kolodgie F, Lutter C, Mori H, Romero M, Finn A . Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2016; 37(2):191-204. PMC: 5269516. DOI: 10.1161/ATVBAHA.116.306256. View

14.

Turillazzi E, Neri M, Cerretani D, Cantatore S, Frati P, Moltoni L . Lipid peroxidation and apoptotic response in rat brain areas induced by long-term administration of nandrolone: the mutual crosstalk between ROS and NF-kB. J Cell Mol Med. 2016; 20(4):601-12. PMC: 5125979. DOI: 10.1111/jcmm.12748. View

15.

Al-Aly Z . Phosphate, oxidative stress, and nuclear factor-κB activation in vascular calcification. Kidney Int. 2011; 79(10):1044-7. DOI: 10.1038/ki.2010.548. View

16.

Ruffenach G, Chabot S, Tanguay V, Courboulin A, Boucherat O, Potus F . Role for Runt-related Transcription Factor 2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2016; 194(10):1273-1285. DOI: 10.1164/rccm.201512-2380OC. View

17.

Shanahan C, Crouthamel M, Kapustin A, Giachelli C . Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res. 2011; 109(6):697-711. PMC: 3249146. DOI: 10.1161/CIRCRESAHA.110.234914. View

18.

Golob M, Tian L, Wang Z, Zimmerman T, Caneba C, Hacker T . Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function. J Biomech. 2015; 48(3):405-12. PMC: 4306604. DOI: 10.1016/j.jbiomech.2014.12.044. View

19.

Li P, Dietz R, von Harsdorf R . Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells. Circulation. 1997; 96(10):3602-9. DOI: 10.1161/01.cir.96.10.3602. View

20.

Stewart J, Chinnery P . The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease. Nat Rev Genet. 2015; 16(9):530-42. DOI: 10.1038/nrg3966. View