A Mild Synthesis of Vinyl Halides and Gem-dihalides Using Triphenyl Phosphite-halogen-based Reagents

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2007 Feb 14

PMID 17295542

Citations 19

Authors

Alberto Spaggiari

Daniele Vaccari

Paolo Davoli

Giovanni Torre

Fabio Prati

Affiliations

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Abstract

A new application of (PhO)3P-halogen-based reagents to the synthesis of vinyl halides and gem-dihalides is described. Vinyl halides were prepared in good to excellent yields from enolizable ketones, whereas aldehydes afforded the corresponding gem-dihalides. The halogenation proceeded smoothly under mild conditions.

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