Nickel-Catalyzed Conversion of Enol Triflates into Alkenyl Halides

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2019 Aug 15

PMID 31410936

Citations 8

Authors

Julie L Hofstra

Kelsey E Poremba

Alex M Shimozono

Sarah E Reisman

Affiliations

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Abstract

A Ni-catalyzed halogenation of enol triflates was developed and it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench-stable Ni(OAc) ⋅4 H O as a precatalyst and proceeds at room temperature in the presence of sub-stoichiometric Zn and either 1,5-cyclooctadiene or 4-(N,N-dimethylamino)pyridine.

Citing Articles

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