Antibody Response to Serotype-specific and Cross-reactive Neutralization Epitopes on VP4 and VP7 After Rotavirus Infection or Vaccination

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1991 Mar 1

PMID 1709946

Citations 17

Authors

K Taniguchi

T Urasawa

N Kobayashi

M U Ahmed

N Adachi

S Chiba

S URASAWA

Affiliations

Soon will be listed here.

Abstract

By using a competitive solid-phase immunoassay with serotype-specific and cross-reactive neutralizing monoclonal antibodies directed at VP4 and VP7, we tested the antibody responses to some neutralization epitopes on VP4 and VP7 in individuals infected or vaccinated with rotavirus. Antibody responses to VP7 epitopes of the infecting serotype of virus were found at a high frequency in both infants and children. In contrast, antibody responses to VP4 and heterotypic VP7 were observed only when the individuals possessed antibodies to any serotype of rotavirus in their acute-phase or prevaccination sera.

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References

Deutsch S, Vinit M, BUSSARD A . Original antigenic sin at the cellular level. II. Specificity of the antibodies produced by individual cells. Eur J Immunol. 1973; 3(4):235-40. DOI: 10.1002/eji.1830030411. View

URASAWA S, Urasawa T, Taniguchi K, Chiba S . Serotype determination of human rotavirus isolates and antibody prevalence in pediatric population in Hokkaido, Japan. Arch Virol. 1984; 81(1-2):1-12. DOI: 10.1007/BF01309292. View

Kobayashi N, Taniguchi K, URASAWA S . Analysis of the newly identified neutralization epitopes on VP7 of human rotavirus serotype 1. J Gen Virol. 1991; 72 ( Pt 1):117-24. DOI: 10.1099/0022-1317-72-1-117. View

Kobayashi N, Taniguchi K, URASAWA S . Identification of operationally overlapping and independent cross-reactive neutralization regions on human rotavirus VP4. J Gen Virol. 1990; 71 ( Pt 11):2615-23. DOI: 10.1099/0022-1317-71-11-2615. View

Urasawa T, Taniguchi K, Kobayashi N, WAKASUGI F, Oishi I, Minekawa Y . Antigenic and genetic analyses of human rotavirus with dual subgroup specificity. J Clin Microbiol. 1990; 28(12):2837-41. PMC: 268290. DOI: 10.1128/jcm.28.12.2837-2841.1990. View

Clark H, Borian F, Bell L, Modesto K, Gouvea V, Plotkin S . Protective effect of WC3 vaccine against rotavirus diarrhea in infants during a predominantly serotype 1 rotavirus season. J Infect Dis. 1988; 158(3):570-87. PMC: 7110070. DOI: 10.1093/infdis/158.3.570. View

Gorziglia M, Green K, Nishikawa K, Taniguchi K, Jones R, Kapikian A . Sequence of the fourth gene of human rotaviruses recovered from asymptomatic or symptomatic infections. J Virol. 1988; 62(8):2978-84. PMC: 253736. DOI: 10.1128/JVI.62.8.2978-2984.1988. View

Svensson L, Sheshberadaran H, Vene S, Norrby E, Grandien M, Wadell G . Serum antibody responses to individual viral polypeptides in human rotavirus infections. J Gen Virol. 1987; 68 ( Pt 3):643-51. DOI: 10.1099/0022-1317-68-3-643. View

Ward R, Bernstein D, Young E, Sherwood J, Knowlton D, Schiff G . Human rotavirus studies in volunteers: determination of infectious dose and serological response to infection. J Infect Dis. 1986; 154(5):871-80. DOI: 10.1093/infdis/154.5.871. View

10.

Hoshino Y, Sereno M, Midthun K, Flores J, Kapikian A, Chanock R . Independent segregation of two antigenic specificities (VP3 and VP7) involved in neutralization of rotavirus infectivity. Proc Natl Acad Sci U S A. 1985; 82(24):8701-4. PMC: 391504. DOI: 10.1073/pnas.82.24.8701. View

11.

Offit P, Blavat G . Identification of the two rotavirus genes determining neutralization specificities. J Virol. 1986; 57(1):376-8. PMC: 252740. DOI: 10.1128/JVI.57.1.376-378.1986. View

12.

Taniguchi K, Urasawa T, Morita Y, Greenberg H, URASAWA S . Direct serotyping of human rotavirus in stools by an enzyme-linked immunosorbent assay using serotype 1-, 2-, 3-, and 4-specific monoclonal antibodies to VP7. J Infect Dis. 1987; 155(6):1159-66. DOI: 10.1093/infdis/155.6.1159. View

13.

Taniguchi K, Nishikawa K, Urasawa T, URASAWA S, Midthun K, Kapikian A . Complete nucleotide sequence of the gene encoding VP4 of a human rotavirus (strain K8) which has unique VP4 neutralization epitopes. J Virol. 1989; 63(9):4101-6. PMC: 251016. DOI: 10.1128/JVI.63.9.4101-4106.1989. View

14.

Matsui S, Mackow E, Greenberg H . Molecular determinant of rotavirus neutralization and protection. Adv Virus Res. 1989; 36:181-214. DOI: 10.1016/s0065-3527(08)60585-0. View

15.

Taniguchi K, Maloy W, Nishikawa K, Green K, Hoshino Y, URASAWA S . Identification of cross-reactive and serotype 2-specific neutralization epitopes on VP3 of human rotavirus. J Virol. 1988; 62(7):2421-6. PMC: 253400. DOI: 10.1128/JVI.62.7.2421-2426.1988. View

16.

Morita Y, Taniguchi K, Urasawa T, URASAWA S . Analysis of serotype-specific neutralization epitopes on VP7 of human rotavirus by the use of neutralizing monoclonal antibodies and antigenic variants. J Gen Virol. 1988; 69 ( Pt 2):451-8. DOI: 10.1099/0022-1317-69-2-451. View

17.

Taniguchi K, Hoshino Y, Nishikawa K, Green K, Maloy W, Morita Y . Cross-reactive and serotype-specific neutralization epitopes on VP7 of human rotavirus: nucleotide sequence analysis of antigenic mutants selected with monoclonal antibodies. J Virol. 1988; 62(6):1870-4. PMC: 253268. DOI: 10.1128/JVI.62.6.1870-1874.1988. View

18.

Shaw R, Fong K, Losonsky G, Levine M, Maldonado Y, Yolken R . Epitope-specific immune responses to rotavirus vaccination. Gastroenterology. 1987; 93(5):941-50. DOI: 10.1016/0016-5085(87)90555-5. View

19.

Coulson B, Tursi J, McAdam W, Bishop R . Derivation of neutralizing monoclonal antibodies to human rotaviruses and evidence that an immunodominant neutralization site is shared between serotypes 1 and 3. Virology. 1986; 154(2):302-12. DOI: 10.1016/0042-6822(86)90456-3. View

20.

Shaw R, Vo P, Offit P, Coulson B, Greenberg H . Antigenic mapping of the surface proteins of rhesus rotavirus. Virology. 1986; 155(2):434-51. DOI: 10.1016/0042-6822(86)90205-9. View