Resveratrol Improves Health and Survival of Mice on a High-calorie Diet

Overview

Journal Nature

Specialty Science

Date 2006 Nov 7

PMID 17086191

Citations 1737

Authors

Joseph A Baur

Kevin J Pearson

Nathan L Price

Hamish A Jamieson

Carles Lerin

Avash Kalra

Vinayakumar V Prabhu

Joanne S Allard

Guillermo Lopez-Lluch

Kaitlyn Lewis

Paul J Pistell

Suresh Poosala

Kevin G Becker

Olivier Boss

Dana Gwinn

Mingyi Wang

Sharan Ramaswamy

Kenneth W Fishbein

Richard G Spencer

Edward G Lakatta

David Le Couteur

Reuben J Shaw

Placido Navas

Pere Puigserver

Donald K Ingram

Rafael de Cabo

David A Sinclair

Affiliations

Soon will be listed here.

Abstract

Resveratrol (3,5,4'-trihydroxystilbene) extends the lifespan of diverse species including Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these organisms, lifespan extension is dependent on Sir2, a conserved deacetylase proposed to underlie the beneficial effects of caloric restriction. Here we show that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) activity, increased mitochondrial number, and improved motor function. Parametric analysis of gene set enrichment revealed that resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing.

Citing Articles

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