Edward G Lakatta
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Explore the profile of Edward G Lakatta including associated specialties, affiliations and a list of published articles.
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405
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26377
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Recent Articles
1.
DAgostino M, Sileno S, Lulli D, De Luca N, Scarponi C, Teson M, et al.
J Biomed Sci
. 2025 Feb;
32(1):21.
PMID: 39948670
Background: Reactive oxygen species (ROS) are increased in diabetic conditions and play a causal role in diabetic foot ulcers (DFU). We previously showed that ROS up-regulate miR-200c expression, that in...
2.
Frankowski D, Ferrucci L, Arany P, Bowers D, Eells J, Gonzalez-Lima F, et al.
Geroscience
. 2025 Jan;
PMID: 39826026
Photobiomodulation (PBM) therapy, a non-thermal light therapy using nonionizing light sources, has shown therapeutic potential across diverse biological processes, including aging and age-associated diseases. In 2023, scientists from the National...
3.
Vinogradova T, Lakatta E
Cells
. 2025 Jan;
14(1.
PMID: 39791704
The spontaneous firing of the sinoatrial (SA) node, the physiological pacemaker of the heart, is generated within sinoatrial nodal cells (SANCs) and is regulated by a "coupled-clock" pacemaker system, which...
4.
Maltsev A, Ventura Subirachs V, Monfredi O, Juhaszova M, Ajay Warrier P, Rakshit S, et al.
Cells
. 2024 Nov;
13(22).
PMID: 39594633
The rate of spontaneous action potentials (APs) generated by sinoatrial node cells (SANC) is regulated by local Ca release (LCR) from the sarcoplasmic reticulum via Ca release channels (ryanodine receptors,...
5.
Moghtadaei M, Tagirova S, Ahmet I, Moen J, Lakatta E, Rose R
Geroscience
. 2024 Jul;
46(5):5085-5101.
PMID: 38967697
Aging is a major risk factor for sinoatrial node (SAN) dysfunction, which can impair heart rate (HR) control and heart rate variability (HRV). HR and HRV are determined by intrinsic...
6.
Alghatrif M, Morrell C, Fleg J, Chantler P, Najjar S, Becker L, et al.
Am J Physiol Heart Circ Physiol
. 2024 Jun;
327(2):H509-H517.
PMID: 38874616
Aging is associated with a significant decline in aerobic capacity assessed by maximal exercise oxygen consumption (V̇o). The relative contributions of the specific V̇o components driving this decline, namely cardiac...
7.
Florio M, Fusini L, Tamborini G, Morrell C, McDonald A, Walcott M, et al.
Geroscience
. 2024 Apr;
46(5):4615-4634.
PMID: 38689157
Aging per se is a major risk factor for cardiovascular diseases and is associated with progressive changes in cardiac structure and function. Rodent models are commonly used to study cardiac...
8.
Keaton J, Kamali Z, Xie T, Vaez A, Williams A, Goleva S, et al.
Nat Genet
. 2024 Apr;
56(5):778-791.
PMID: 38689001
Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10) from the largest...
9.
Kumar V, Bermea K, Kumar D, Singh A, Verma A, Kaileh M, et al.
Geroscience
. 2024 Mar;
46(5):4243-4262.
PMID: 38499959
Mice with cardiac-specific overexpression of adenylyl cyclase (AC) type 8 (TG) are under a constant state of severe myocardial stress. They have a remarkable ability to adapt to this stress,...
10.
Qu J, Chakir K, Tarasov K, Riordon D, Perino M, Silvester A, et al.
Elife
. 2024 Jan;
12.
PMID: 38251682
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included overexpression of a large...