Two Separate Molecular Systems, Dachsous/Fat and Starry Night/Frizzled, Act Independently to Confer Planar Cell Polarity

Overview

Journal Development

Specialty Biology

Date 2006 Nov 1

PMID 17075008

Citations 120

Authors

Jose Casal

Peter A Lawrence

Gary Struhl

Affiliations

Soon will be listed here.

Abstract

Planar polarity is a fundamental property of epithelia in animals and plants. In Drosophila it depends on at least two sets of genes: one set, the Ds system, encodes the cadherins Dachsous (Ds) and Fat (Ft), as well as the Golgi protein Four-jointed. The other set, the Stan system, encodes Starry night (Stan or Flamingo) and Frizzled. The prevailing view is that the Ds system acts via the Stan system to orient cells. However, using the Drosophila abdomen, we find instead that the two systems operate independently: each confers and propagates polarity, and can do so in the absence of the other. We ask how the Ds system acts; we find that either Ds or Ft is required in cells that send information and we show that both Ds and Ft are required in the responding cells. We consider how polarity may be propagated by Ds-Ft heterodimers acting as bridges between cells.

Citing Articles

Contributions of the Dachsous intracellular domain to Dachsous-Fat signaling.

Tripathi B, Irvine K Development. 2024; 151(23).

PMID: 39503213 PMC: 11634027. DOI: 10.1242/dev.202919.

Emergence of planar cell polarity from the interplay of local interactions and global gradients.

Singh D, Ramaswamy S, Jolly M, Rizvi M Elife. 2024; 13.

PMID: 39450855 PMC: 11602187. DOI: 10.7554/eLife.84053.

Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation.

Kacker S, Parsad V, Singh N, Hordiichuk D, Alvarez S, Gohar M J Dev Biol. 2024; 12(2).

PMID: 38804432 PMC: 11130840. DOI: 10.3390/jdb12020012.

Planar cell polarity: intracellular asymmetry and supracellular gradients of Frizzled.

Casal J, Storer F, Lawrence P Open Biol. 2023; 13(6):230105.

PMID: 37311537 PMC: 10264100. DOI: 10.1098/rsob.230105.

Planar cell polarity: intracellular asymmetry and supracellular gradients of Dachsous.

Chorro A, Verma B, Homfeldt M, Ibanez B, Lawrence P, Casal J Open Biol. 2022; 12(10):220195.

PMID: 36476047 PMC: 9554717. DOI: 10.1098/rsob.220195.

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