Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation

Overview

Journal J Dev Biol

Specialty Biology

Date 2024 May 28

PMID 38804432

Authors

Sandeep Kacker

Varuneshwar Parsad

Naveen Singh

Daria Hordiichuk

Stacy Alvarez

Mahnoor Gohar

Anshu Kacker

Sunil Kumar Rai

Affiliations

Soon will be listed here.

Abstract

The planar cell polarity (PCP) system is essential for positioning cells in 3D networks to establish the proper morphogenesis, structure, and function of organs during embryonic development. The PCP system uses inter- and intracellular feedback interactions between components of the core PCP, characterized by coordinated planar polarization and asymmetric distribution of cell populations inside the cells. PCP signaling connects the anterior-posterior to left-right embryonic plane polarity through the polarization of cilia in the Kupffer's vesicle/node in vertebrates. Experimental investigations on various genetic ablation-based models demonstrated the functions of PCP in planar polarization and associated genetic disorders. This review paper aims to provide a comprehensive overview of PCP signaling history, core components of the PCP signaling pathway, molecular mechanisms underlying PCP signaling, interactions with other signaling pathways, and the role of PCP in organ and embryonic development. Moreover, we will delve into the negative feedback regulation of PCP to maintain polarity, human genetic disorders associated with PCP defects, as well as challenges associated with PCP.

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