Expression of SOX9 and SOX10 in Central Neuroepithelial Tumor

Overview

Journal J Neurooncol

Publisher Springer

Date 2006 Jun 23

PMID 16791471

Citations 25

Authors

U Kordes

C Hagel

Affiliations

Soon will be listed here.

Abstract

The SOX group E transcription factors play an integral role in the specification and differentiation of astrocytes and oligodendrocytes. We have examined the pattern of expression for SOX9 and SOX10 in primary brain tumors by immunohistochemistry. Pediatric and adult high grade tumors display strong nuclear staining for both SOX9 and SOX10 (astrocytic, oligodendroglial and primitive neuroectodermal tumors). In comparison pediatric pilocytic astrocytoma express much less SOX9 and SOX10. Reactive astrogliosis is characterized by an increase of SOX9 only.

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