Role of SOX Family of Transcription Factors in Central Nervous System Tumors

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2014 Jul 25

PMID 25057435

Citations 51

Authors

Arlet M Acanda de la Rocha

Nicolas Sampron

Marta M Alonso

Ander Matheu

Affiliations

Soon will be listed here.

Abstract

SOX genes are developmental regulators with functions in the instruction of cell fate and maintenance of progenitor's identity during embryogenesis. They play additional roles during tissue homeostasis and regeneration in adults particularly in the Central Nervous System (CNS). In the last years a growing number of evidences has shown that mutations and dysfunction of SOX factors are implicated in several human diseases, including a variety of cancers. In this review, we will summarize the current knowledge about SOX family in CNS tumors and their role in the origin and maintenance of the subpopulation of cancer stem cells in these tumors.

Citing Articles

INSTINCT: Multi-sample integration of spatial chromatin accessibility sequencing data via stochastic domain translation.

Liu Y, Li Z, Chen X, Cui X, Gao Z, Jiang R Nat Commun. 2025; 16(1):1247.

PMID: 39893190 PMC: 11787322. DOI: 10.1038/s41467-025-56535-0.

A cutting-edge investigation of the multifaceted role of SOX family genes in cancer pathogenesis through the modulation of various signaling pathways.

Jasim S, Farhan S, Ahmad I, Hjazi A, Kumar A, Abed Jawad M Funct Integr Genomics. 2025; 25(1):6.

PMID: 39753912 DOI: 10.1007/s10142-024-01517-6.

Implementation of the Methyl-Seq platform to identify tissue- and sex-specific DNA methylation differences in the rat epigenome.

Cox O, Seifuddin F, Guo J, Pirooznia M, Boersma G, Wang J Epigenetics. 2024; 19(1):2393945.

PMID: 39306700 PMC: 11418217. DOI: 10.1080/15592294.2024.2393945.

The generation of glioma organoids and the comparison of two culture methods.

Zhang Y, Shao Y, Li Y, Li X, Zhang X, E Q Cancer Med. 2024; 13(4):e7081.

PMID: 38457217 PMC: 10923046. DOI: 10.1002/cam4.7081.

Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues.

Zhao X, Song L, Yang A, Zhang Z, Zhang J, Yang Y Genome Med. 2023; 15(1):56.

PMID: 37488639 PMC: 10364416. DOI: 10.1186/s13073-023-01210-6.

References

Ballester L, Wang Z, Shandilya S, Miettinen M, Burger P, Eberhart C . Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas. Am J Surg Pathol. 2013; 37(9):1357-64. PMC: 3787318. DOI: 10.1097/PAS.0b013e318294e817. View

Hide T, Takezaki T, Nakatani Y, Nakamura H, Kuratsu J, Kondo T . Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer Res. 2009; 69(20):7953-9. DOI: 10.1158/0008-5472.CAN-09-2006. View

Rakic P . DNA synthesis and cell division in the adult primate brain. Ann N Y Acad Sci. 1985; 457:193-211. DOI: 10.1111/j.1749-6632.1985.tb20806.x. View

Pritchett J, Athwal V, Roberts N, Hanley N, Piper Hanley K . Understanding the role of SOX9 in acquired diseases: lessons from development. Trends Mol Med. 2011; 17(3):166-74. DOI: 10.1016/j.molmed.2010.12.001. View

Bao S, Wu Q, McLendon R, Hao Y, Shi Q, Hjelmeland A . Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006; 444(7120):756-60. DOI: 10.1038/nature05236. View

de Almeida Galatro T, Uno M, Oba-Shinjo S, Almeida A, Teixeira M, Rosemberg S . Differential expression of ID4 and its association with TP53 mutation, SOX2, SOX4 and OCT-4 expression levels. PLoS One. 2013; 8(4):e61605. PMC: 3628974. DOI: 10.1371/journal.pone.0061605. View

Hagerstrand D, He X, Bradic Lindh M, Hoefs S, Hesselager G, Ostman A . Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile. Neuro Oncol. 2011; 13(11):1178-91. PMC: 3199157. DOI: 10.1093/neuonc/nor113. View

Friedmann-Morvinski D, Bushong E, Ke E, Soda Y, Marumoto T, Singer O . Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science. 2012; 338(6110):1080-4. PMC: 3595315. DOI: 10.1126/science.1226929. View

Taranova O, Magness S, Fagan B, Wu Y, Surzenko N, Hutton S . SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev. 2006; 20(9):1187-202. PMC: 1472477. DOI: 10.1101/gad.1407906. View

10.

Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K . Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Mol Med. 2012; 4(3):218-33. PMC: 3305999. DOI: 10.1002/emmm.201100201. View

11.

Crocetti E, Trama A, Stiller C, Caldarella A, Soffietti R, Jaal J . Epidemiology of glial and non-glial brain tumours in Europe. Eur J Cancer. 2012; 48(10):1532-42. DOI: 10.1016/j.ejca.2011.12.013. View

12.

Lin B, Madan A, Yoon J, Fang X, Yan X, Kim T . Massively parallel signature sequencing and bioinformatics analysis identifies up-regulation of TGFBI and SOX4 in human glioblastoma. PLoS One. 2010; 5(4):e10210. PMC: 2856677. DOI: 10.1371/journal.pone.0010210. View

13.

Wang J, Wakeman T, Lathia J, Hjelmeland A, Wang X, White R . Notch promotes radioresistance of glioma stem cells. Stem Cells. 2009; 28(1):17-28. PMC: 2825687. DOI: 10.1002/stem.261. View

14.

Kanamori M, Kawaguchi T, Nigro J, Feuerstein B, Berger M, Miele L . Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg. 2007; 106(3):417-27. DOI: 10.3171/jns.2007.106.3.417. View

15.

Fang X, Yoon J, Li L, Yu W, Shao J, Hua D . The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis. BMC Genomics. 2011; 12:11. PMC: 3022822. DOI: 10.1186/1471-2164-12-11. View

16.

Broniscer A, Gajjar A . Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist. Oncologist. 2004; 9(2):197-206. DOI: 10.1634/theoncologist.9-2-197. View

17.

Ellis P, Fagan B, Magness S, Hutton S, Taranova O, Hayashi S . SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev Neurosci. 2005; 26(2-4):148-65. DOI: 10.1159/000082134. View

18.

Visvader J . Cells of origin in cancer. Nature. 2011; 469(7330):314-22. DOI: 10.1038/nature09781. View

19.

Gajjar A, Packer R, Foreman N, Cohen K, Haas-Kogan D, Merchant T . Children's Oncology Group's 2013 blueprint for research: central nervous system tumors. Pediatr Blood Cancer. 2012; 60(6):1022-6. PMC: 4184243. DOI: 10.1002/pbc.24427. View

20.

Ruiz i Altaba A, Sanchez P, Dahmane N . Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer. 2002; 2(5):361-72. DOI: 10.1038/nrc796. View