Discovery of Novel Heterocyclic Factor VIIa Inhibitors
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Abstract
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.
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PMID: 27363788 PMC: 4950954. DOI: 10.1039/c6cc04735a.