Ellen Sanford
Overview
Explore the profile of Ellen Sanford including associated specialties, affiliations and a list of published articles.
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5
Citations
8
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Recent Articles
1.
Hu H, Kolesnikov A, Riggs J, Wesson K, Stephens R, Leahy E, et al.
Bioorg Med Chem Lett
. 2006 Jun;
16(17):4567-70.
PMID: 16793264
The 4-amino-5-azaindole as an amidino-benzimidazole replacement is described. A series of potent and selective analogs were discovered and showed desirable ex vivo efficacy as measured by PT.
2.
Vijaykumar D, Rai R, Shaghafi M, Ton T, Torkelson S, Leahy E, et al.
Bioorg Med Chem Lett
. 2006 May;
16(14):3829-32.
PMID: 16650987
Efforts toward developing orally bioavailable factor VIIa inhibitors starting from parenteral lead compound 1 are described. SAR resulted in improved physicochemical properties, leading to enhanced oral absorption in rat.
3.
Riggs J, Hu H, Kolesnikov A, Leahy E, Wesson K, Shrader W, et al.
Bioorg Med Chem Lett
. 2006 Apr;
16(12):3197-200.
PMID: 16621549
The discovery and development of 5-azaindole factor VIIa inhibitors will be described.
4.
Rai R, Kolesnikov A, Sprengeler P, Torkelson S, Ton T, Katz B, et al.
Bioorg Med Chem Lett
. 2006 Feb;
16(8):2270-3.
PMID: 16460932
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic...
5.
Shrader W, Kolesnikov A, Burgess-Henry J, Rai R, Hendrix J, Hu H, et al.
Bioorg Med Chem Lett
. 2006 Jan;
16(6):1596-600.
PMID: 16413783
Within the trypsin family of coagulation proteases, obtaining highly selective inhibitors of factor VIIa has been challenging. We report a series of factor VIIa (fVIIa) inhibitors based on the 5-amidino-2-(2-hydroxy-biphenyl-3-yl)-benzimidazole...