Novel Cyclic Lipodepsipeptide from Pseudomonas Syringae Pv. Lachrymans Strain 508 and Syringopeptin Antimicrobial Activities

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2005 Nov 24

PMID 16304170

Citations 14

Authors

Ingeborg Grgurina

Mekki Bensaci

Gabriella Pocsfalvi

Luisa Mannina

Oscar Cruciani

Alberto Fiore

Vincenzo Fogliano

Kevin N Sorensen

Jon Y Takemoto

Affiliations

Soon will be listed here.

Abstract

The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP508 differed from SP22 and other syringopeptins by having three instead of four alpha,beta-unsaturated amino acids and a longer beta-hydroxy acyl chain. Both SP508 and SP22 displayed growth-inhibitory activities against Mycobacterium smegmatis, other gram-positive bacteria, and yeasts but not against gram-negative bacteria. Structure-activity analyses of the SP508 and SP22 homologs indicated chemical structural features that lead to enhanced antimycobacterial activity by these pseudomonad cyclic lipodepsipeptides.

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