Differential Antibiotic Susceptibilities of Starved Mycobacterium Tuberculosis Isolates

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2005 Oct 28

PMID 16251329

Citations 78

Authors

Zhifang Xie

Noman Siddiqi

Eric J Rubin

Affiliations

Soon will be listed here.

Abstract

We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells. These drugs appear to target a process important in both replicating and nonreplicating bacteria.

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