Noman Siddiqi
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Explore the profile of Noman Siddiqi including associated specialties, affiliations and a list of published articles.
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10
Citations
605
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Recent Articles
1.
OHara J, Wakabayashi S, Siddiqi N, Cheung E, Babunovic G, Thompson C, et al.
mBio
. 2023 Feb;
14(1):e0361122.
PMID: 36749098
Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide. To date, the mainstay of vaccination involves the use of Mycobacterium bovis bacillus Calmette-Guérin (BCG), a live-attenuated vaccine that...
2.
Martinot A, Blass E, Yu J, Aid M, Mahrokhian S, Cohen S, et al.
PLoS Pathog
. 2020 Dec;
16(12):e1009096.
PMID: 33315936
Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to...
3.
Buter J, Cheng T, Ghanem M, Grootemaat A, Raman S, Feng X, et al.
Nat Chem Biol
. 2019 Aug;
15(9):889-899.
PMID: 31427817
Mycobacterium tuberculosis (Mtb) is the world's most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene nucleoside of unknown function. In the present study 1-TbAd has...
4.
Wellington S, Nag P, Michalska K, Johnston S, Jedrzejczak R, Kaushik V, et al.
Nat Chem Biol
. 2017 Jul;
13(9):943-950.
PMID: 28671682
New antibiotics with novel targets are greatly needed. Bacteria have numerous essential functions, but only a small fraction of such processes-primarily those involved in macromolecular synthesis-are inhibited by current drugs....
5.
Stanley S, Barczak A, Silvis M, Luo S, Sogi K, Vokes M, et al.
PLoS Pathog
. 2014 Mar;
10(2):e1003946.
PMID: 24586159
Mycobacterium tuberculosis remains a significant threat to global health. Macrophages are the host cell for M. tuberculosis infection, and although bacteria are able to replicate intracellularly under certain conditions, it...
6.
Siegrist M, Unnikrishnan M, McConnell M, Borowsky M, Cheng T, Siddiqi N, et al.
Proc Natl Acad Sci U S A
. 2009 Oct;
106(44):18792-7.
PMID: 19846780
The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized system, is required for virulence of Mycobacterium tuberculosis, although its precise function during infection remains unclear. Esx-3, a...
7.
Ranjbar S, Boshoff H, Mulder A, Siddiqi N, Rubin E, Goldfeld A
PLoS One
. 2009 Jul;
4(7):e6116.
PMID: 19568431
Background: Tuberculosis (TB) is the largest cause of death in human immunodeficiency virus type 1 (HIV-1) infection, having claimed an estimated one third to one half of the 30 million...
8.
Diaz R, Siddiqi N, Rubin E
Tuberculosis (Edinb)
. 2006 Apr;
86(3-4):314-8.
PMID: 16644284
Recent advances in functional and comparative genomics have improved our understanding of genetic diversity among the Mycobacterium tuberculosis complex. In this study, we investigated the genetic polymorphism of M. tuberculosis...
9.
Xie Z, Siddiqi N, Rubin E
Antimicrob Agents Chemother
. 2005 Oct;
49(11):4778-80.
PMID: 16251329
We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations...
10.
Siddiqi N, Shamim M, Hussain S, Choudhary R, Ahmed N, Prachee , et al.
Antimicrob Agents Chemother
. 2002 Jan;
46(2):443-50.
PMID: 11796356
The World Health Organization has identified India as a major hot-spot region for Mycobacterium tuberculosis infection. We have characterized the sequences of the loci associated with multidrug resistance in 126...